Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRIM24 | O15164 | 1/20 | 0.49 |
| ▸ | BRD1 | O95696 | 1/20 | 0.49 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.49 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | KIT | P10721 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7573977 | 0.75 | PKM (0.64) | TRIM24BRD1BRPF1POLBKIT | |
| SCHEMBL7835318 | 0.74 | HTR6 (0.72) | SMN1; SMN2ALDH1A1MAPTLMNAGSK3B | |
| SCHEMBL11977002 | 0.73 | KDM4E (0.70) | POLBSMN1; SMN2ALDH1A1LMNAPKM | |
| SCHEMBL7175064 | 0.72 | HSD17B2 (0.67) | TRIM24BRD1BRPF1GFERSMN1; SMN2 | |
| SCHEMBL7176650 | 0.71 | LMNA (0.62) | TRIM24BRD1BRPF1GFERPOLB | |
| SCHEMBL14803278 | 0.71 | AURKA (0.68) | POLBSMN1; SMN2ALDH1A1MAPTLMNA | |
| SCHEMBL31681359 | 0.71 | LMNA (0.58) | TRIM24BRD1BRPF1SMN1; SMN2ALDH1A1 | |
| SCHEMBL1415291 | 0.71 | TRIM24 (0.58) | TRIM24BRD1BRPF1POLBKIT | |
| Hydrochloric Acid SCHEMBL1973363 | 0.70 | TRIM24 (0.56) | TRIM24BRD1BRPF1POLBKIT | |
| SCHEMBL14349660 | 0.69 | CA1 (0.61) | TRIM24BRD1BRPF1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7867999-B1 | Hydroxyamino- and amino-substituted pyridine analogs for treating rho kinase-mediated diseases and conditions | ALCON RESEARCH, LTD. (US) | 2011-01-11 | — | — | US | disclosed |