Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 8/20 | 0.64 |
| ▸ | PKLR | P30613 | 2/20 | 0.62 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.59 |
| ▸ | BRD1 | O95696 | 1/20 | 0.59 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | PGR | P06401 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | KIT | P10721 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12903520 | 0.84 | PKM (0.68) | PKMPKLRMAPTALDH1A1MEN1 | |
| SCHEMBL30532923 | 0.83 | PKM (0.71) | PKMPKLRSMN1; SMN2MAPTLMNA | |
| SCHEMBL14403177 | 0.83 | PKM (0.71) | PKMPKLRSMN1; SMN2MAPTLMNA | |
| SCHEMBL7596280 | 0.82 | CCR2 (0.56) | PKMTRIM24BRD1BRPF1SMN1; SMN2 | |
| SCHEMBL11976998 | 0.82 | ALDH1A1 (0.64) | PKMTRIM24BRD1BRPF1SMN1; SMN2 | |
| SCHEMBL13453842 | 0.82 | GPR55 (0.56) | PKMSMN1; SMN2MAPTLMNAALDH1A1 | |
| SCHEMBL7577338 | 0.80 | PKM (0.69) | PKMPKLRSMN1; SMN2MAPTLMNA | |
| SCHEMBL30343351 | 0.80 | PKM (0.69) | PKMPKLRSMN1; SMN2MAPTLMNA | |
| SCHEMBL31681359 | 0.80 | LMNA (0.58) | PKMTRIM24BRD1BRPF1SMN1; SMN2 | |
| SCHEMBL1415291 | 0.80 | TRIM24 (0.58) | PKMTRIM24BRD1BRPF1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | disclosed |