Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 9/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 7/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.41 |
| ▸ | RELA | Q04206 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6845274 | 0.81 | ROCK2 (0.48) | ROCK2ROCK1MAPTRAB9AKMT2A | |
| SCHEMBL27500826 | 0.80 | MEN1 (0.56) | MAPTPOLBMITFRAB9AKMT2A | |
| SCHEMBL6845275 | 0.80 | ROCK2 (0.47) | ROCK2ROCK1RAB9ANPC1ALDH1A1 | |
| SCHEMBL6845267 | 0.77 | ROCK2 (0.71) | ROCK2ROCK1MAPTPOLBMAPK1 | |
| SCHEMBL6845277 | 0.77 | ROCK2 (0.44) | ROCK2ROCK1RAB9AKMT2ANPC1 | |
| SCHEMBL16964837 | 0.72 | POLB (0.56) | MAPTPOLBMAPK1MITFRAB9A | |
| SCHEMBL6557961 | 0.68 | ROCK2 (0.68) | ROCK2ROCK1MAPTPOLBMAPK1 | |
| SCHEMBL11621907 | 0.68 | MAPT (0.54) | MAPTPOLBMAPK1MITFKMT2A | |
| SCHEMBL1880283 | 0.66 | ALDH1A1 (0.50) | MAPTMAPK1RAB9AKMT2ANPC1 | |
| SCHEMBL11618215 | 0.66 | KMT2A (0.41) | MAPTPOLBMAPK1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7867999-B1 | Hydroxyamino- and amino-substituted pyridine analogs for treating rho kinase-mediated diseases and conditions | ALCON RESEARCH, LTD. (US) | 2011-01-11 | — | — | US | disclosed |