Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.44 |
| ▸ | BRAF | P15056 | 2/20 | 0.41 |
| ▸ | TYK2 | P29597 | 5/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | TEK | Q02763 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6845264 | 0.89 | RAB9A (0.51) | ROCK2ROCK1BRAFTYK2JAK2 | |
| SCHEMBL988281 | 0.87 | ROCK2 (0.61) | ROCK2ROCK1BRAFTYK2JAK2 | |
| SCHEMBL6845275 | 0.87 | ROCK2 (0.47) | ROCK2ROCK1BRAFTYK2JAK2 | |
| SCHEMBL6845274 | 0.81 | ROCK2 (0.48) | ROCK2ROCK1ALDH1A1MEN1KMT2A | |
| SCHEMBL6845267 | 0.77 | ROCK2 (0.71) | ROCK2ROCK1TYK2JAK2ALDH1A1 | |
| SCHEMBL6845271 | 0.77 | ROCK2 (0.44) | ROCK2ROCK1ALDH1A1MEN1KMT2A | |
| SCHEMBL987306 | 0.73 | ROCK2 (0.65) | ROCK2ROCK1BRAFTYK2JAK2 | |
| SCHEMBL6559116 | 0.72 | ROCK2 (0.64) | ROCK2ROCK1BRAFTYK2JAK2 | |
| SCHEMBL27615981 | 0.68 | KCNK9 (0.69) | TYK2JAK2ALDH1A1MEN1PKM | |
| SCHEMBL987766 | 0.68 | ROCK2 (0.63) | ROCK2ROCK1BRAFTYK2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7867999-B1 | Hydroxyamino- and amino-substituted pyridine analogs for treating rho kinase-mediated diseases and conditions | ALCON RESEARCH, LTD. (US) | 2011-01-11 | — | — | US | disclosed |