Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6054468 | 0.85 | ALDH1A1 (0.44) | GCKPOLBGAACYP19A1ALDH1A1 | |
| SCHEMBL570633 | 0.84 | KDM4E (0.42) | GCKPOLBGAACYP19A1ALDH1A1 | |
| SCHEMBL20165747 | 0.84 | MEN1 (0.51) | GCKPOLBGAACYP19A1ALDH1A1 | |
| SCHEMBL28455691 | 0.80 | AHR (0.39) | GCKALOX5AP | |
| SCHEMBL11458038 | 0.74 | CYP19A1 (0.54) | CYP19A1ALDH1A1SMN1; SMN2SLC6A4 | |
| SCHEMBL11476143 | 0.74 | RAB9A (0.49) | POLBGAACYP19A1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8803364 | 0.74 | SLC22A12 (0.45) | CYP19A1ALDH1A1SMN1; SMN2ALOX5APFEN1 | |
| SCHEMBL11465936 | 0.72 | LMNA (0.43) | POLBALDH1A1SMN1; SMN2SLC6A4KDM4E | |
| SCHEMBL22820313 | 0.72 | PLCG1 (0.41) | POLBALDH1A1SMN1; SMN2ALOX5APFEN1 | |
| SCHEMBL11459830 | 0.72 | MAPT (0.50) | GCKCYP19A1ALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011115938-A1 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETA - SECRETASE MODULATORS | AMGEN INC. (US) | 2011-09-22 | — | — | WO | disclosed |
| WO-2010030954-A1 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETASECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2010-03-18 | — | — | WO | disclosed |