Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 2/20 | 0.43 |
| ▸ | MC3R | P41968 | 2/20 | 0.43 |
| ▸ | MC1R | Q01726 | 2/20 | 0.43 |
| ▸ | REN | P00797 | 1/20 | 0.39 |
| ▸ | CTSC | P53634 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CTSD | P07339 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.37 |
| ▸ | GHSR | Q92847 | 1/20 | 0.36 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6843141 | 1.00 | MC4R (0.43) | MC4RMC3RMC1RRENCTSC | |
| SCHEMBL14366157 | 0.94 | MC4R (0.42) | MC4RMC3RMC1RRENCTSC | |
| SCHEMBL29394608 | 0.83 | CTSC (0.42) | MC4RMC3RMC1RRENCTSC | |
| SCHEMBL10972441 | 0.81 | LMNA (0.43) | LMNASMN1; SMN2PSMB8PSMB5 | |
| SCHEMBL10653540 | 0.81 | LMNA (0.47) | MC4RMC3RLMNASMN1; SMN2PSMB8 | |
| SCHEMBL6838403 | 0.81 | LMNA (0.47) | MC4RMC3RLMNASMN1; SMN2PSMB8 | |
| SCHEMBL6667620 | 0.80 | PSMB5 (0.44) | LMNASMN1; SMN2PSEN1PSEN2APH1B | |
| SCHEMBL11455942 | 0.80 | CTSC (0.40) | MC4RMC3RMC1RCTSCLMNA | |
| SCHEMBL6666650 | 0.77 | PSMB5 (0.40) | LMNASMN1; SMN2PSEN1PSEN2APH1B | |
| Ambamustine SCHEMBL62822 | 0.76 | LMNA (0.41) | LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6767992-B1 | USED FOR CHEMOTHERAPY AGAINST CANCERS AND IS USED ESPECIALLY FOR MELANOMAS | PTC PHARMA AG (CH) | 2004-07-27 | — | — | US | disclosed |