Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 12/20 | 0.62 |
| ▸ | PTGES | O14684 | 2/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.52 |
| ▸ | PPARG | P37231 | 2/20 | 0.52 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.49 |
| ▸ | F10 | P00742 | 1/20 | 0.49 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.48 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.48 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.47 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.46 |
| ▸ | TMPRSS15 | P98073 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6298124 | 0.92 | FOLH1 (0.57) | FOLH1PRSS1F10PRSS2PRSS3 | |
| SCHEMBL14508907 | 0.87 | FOLH1 (0.75) | FOLH1PTGESALOX5PPARG | |
| SCHEMBL7157229 | 0.82 | FOLH1 (0.51) | FOLH1PRSS1F10PRSS2PRSS3 | |
| SCHEMBL11840819 | 0.81 | PPARG (0.56) | FOLH1PTGESALOX5PPARG | |
| SCHEMBL7300579 | 0.79 | FOLH1 (0.70) | FOLH1PTGESALOX5PPARG | |
| SCHEMBL27513375 | 0.77 | FOLH1 (0.68) | FOLH1PTGESALOX5PPARG | |
| SCHEMBL202409 | 0.76 | SLC7A5 (0.65) | PRSS1PRSS2PRSS3LOXL2 | |
| SCHEMBL288337 | 0.76 | SLC7A5 (0.65) | PRSS1PRSS2PRSS3LOXL2 | |
| SCHEMBL31538733 | 0.76 | SLC7A5 (0.65) | PRSS1PRSS2PRSS3LOXL2 | |
| SCHEMBL202408 | 0.76 | SLC7A5 (0.65) | PRSS1PRSS2PRSS3LOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040220241-A1 | Substituted biphenyl derivatives | MERCK PATENT GMBH (DE) | 2004-11-04 | — | — | US | claimed |
| US-20030135055-A1 | Aminosulfonylbiphenyl derivatives | MERCK PATENT GMBH (DE) | 2003-07-17 | — | — | US | claimed |
| US-20030135055-A1 | Aminosulfonylbiphenyl derivatives | MERCK PATENT GMBH (DE) | 2003-07-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040220241-A1 | Substituted biphenyl derivatives | APOB, F2R, BDKRB1 | FOLH1 3140/4885PTGES 938/4885ALOX5 685/4885 |
| US-20030135055-A1 | Aminosulfonylbiphenyl derivatives | APOB, F12, SERPINB1 | FOLH1 4522/4885PTGES 952/4885ALOX5 1567/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.