SCHEMBL684622

SCHEMBL684622

O=C(N/N=C/c1cc(Cl)cc(Br)c1O)c1cccc(Br)c1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 8/20 0.63
KMT2A Q03164 8/20 0.63
MAPT P10636 7/20 0.63
KDM4E B2RXH2 6/20 0.63
LMNA P02545 5/20 0.63
HTT P42858 4/20 0.63
TDP1 Q9NUW8 4/20 0.63
MAPK1 P28482 2/20 0.63
SIRT1 Q96EB6 6/20 0.60
RAB9A P51151 4/20 0.58
L3MBTL1 Q9Y468 4/20 0.56
NPC1 O15118 4/20 0.56
SMN1; SMN2 Q16637 2/20 0.56
PKM P14618 1/20 0.56
SAE1 Q9UBE0 1/20 0.56
UBA2 Q9UBT2 1/20 0.56
KDM1A O60341 1/20 0.55
POLB P06746 2/20 0.54
PSMD14 O00487 1/20 0.54
MMP2 P08253 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL684847 0.92 KDM1A (0.66) MEN1KMT2AMAPTKDM4ELMNA
SCHEMBL684563 0.91 KDM4E (0.65) MEN1KMT2AMAPTKDM4ELMNA
SCHEMBL684936 0.89 SIRT1 (0.67) MEN1KMT2AMAPTKDM4ELMNA
SCHEMBL684889 0.89 MAPT (0.77) MEN1KMT2AMAPTKDM4ELMNA
SCHEMBL683991 0.88 NPC1 (0.65) MEN1KMT2AMAPTKDM4ELMNA
SCHEMBL684643 0.88 SIRT1 (0.59) MEN1KMT2AMAPTKDM4ELMNA
SCHEMBL21067960 0.86 SIRT1 (0.76) MEN1KMT2AMAPTKDM4ELMNA
SCHEMBL21067961 0.86 SIRT1 (0.76) MEN1KMT2AMAPTKDM4ELMNA
SCHEMBL684808 0.86 MEN1 (0.65) MEN1KMT2AMAPTKDM4ELMNA
SCHEMBL26974363 0.86 MAPT (0.63) MEN1KMT2AMAPTKDM4ELMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8906829-B2 Synergistic algicidal compositions including hydrazone derivatives and copper DOW AGROSCIENCES LLC (US) 2014-12-09 US disclosed
US-8906829-B2 Synergistic algicidal compositions including hydrazone derivatives and copper DOW AGROSCIENCES LLC (US) 2014-12-09 US disclosed
US-20120046170-A1 SYNERGISTIC ALGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-02-23 US disclosed
US-20120046170-A1 SYNERGISTIC ALGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-02-23 US disclosed
WO-2012024494-A1 SYNERGISTIC ALGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-02-23 WO disclosed
US-20120010075-A1 SYNERGISTIC FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-01-12 US disclosed
US-20120010075-A1 SYNERGISTIC FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-01-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120010075-A1 SYNERGISTIC FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER SOD1, CYP51A1, SOD3 MEN1 536/4885KMT2A 1362/4885MAPT 1491/4885
US-20120046170-A1 SYNERGISTIC ALGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER ALG1, SOD1, DHPS MEN1 3435/4885KMT2A 2866/4885MAPT 3866/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.