Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 3/20 | 1.00 |
| ▸ | MAOA | P21397 | 1/20 | 0.78 |
| ▸ | MAOB | P27338 | 1/20 | 0.78 |
| ▸ | RAB9A | P51151 | 5/20 | 0.70 |
| ▸ | NPC1 | O15118 | 4/20 | 0.70 |
| ▸ | HTT | P42858 | 2/20 | 0.70 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.70 |
| ▸ | MAPT | P10636 | 3/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.69 |
| ▸ | CA12 | O43570 | 1/20 | 0.69 |
| ▸ | CA1 | P00915 | 1/20 | 0.69 |
| ▸ | CA2 | P00918 | 1/20 | 0.69 |
| ▸ | CA9 | Q16790 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.67 |
| ▸ | MEN1 | O00255 | 6/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6568266 | 1.00 | KDM1A (1.00) | KDM1AMAOAMAOBRAB9ANPC1 | |
| SCHEMBL2842569 | 1.00 | KDM1A (1.00) | KDM1AMAOAMAOBRAB9ANPC1 | |
| SCHEMBL15853740 | 0.90 | KDM1A (0.81) | KDM1AMAOAMAOBRAB9ANPC1 | |
| SCHEMBL21145712 | 0.89 | KDM1A (0.80) | KDM1AMAOAMAOBRAB9AHTT | |
| SCHEMBL13362126 | 0.89 | KDM1A (0.80) | KDM1AMAOAMAOBRAB9AHTT | |
| SCHEMBL19283316 | 0.88 | KDM1A (1.00) | KDM1AMAOAMAOBRAB9ANPC1 | |
| SCHEMBL15176803 | 0.88 | KDM1A (1.00) | KDM1AMAOAMAOBRAB9ANPC1 | |
| SCHEMBL14712666 | 0.88 | KDM1A (1.00) | KDM1AMAOAMAOBRAB9ANPC1 | |
| Salicylaldehyde Benzoyl Hydrazone SCHEMBL414978 | 0.88 | KDM1A (0.82) | KDM1AMAOAMAOBRAB9ANPC1 | |
| Salicylaldehyde Benzoyl Hydrazone SCHEMBL414977 | 0.88 | KDM1A (0.82) | KDM1AMAOAMAOBRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2744330-B1 | SUBSTITUTED (E)-N'-(1-PHENYLETHYLIDENE) BENZOHYDRAZIDE ANALOGS AS HISTONE DEMETHYLASE INHIITORS | UNIV UTAH RES FOUND (US) | 2020-07-15 | — | — | EP | disclosed |
| EP-3010915-B1 | SUBSTITUTED (3-(5-CHLORO-2-HYDROXYPHENYL)-1-BENZOYL-1H-PYRAZOLE COMPOUNDS AS HISTONE DEMETHYLASE INHIBITORS | UNIV UTAH RES FOUND (US) | 2019-05-08 | — | — | EP | disclosed |
| US-9642857-B2 | Substituted (E)-N′-(1-phenylethylidene)benzohydrazide analogs as histone demethylase inhibitors | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2017-05-09 | — | — | US | disclosed |
| US-9642857-B2 | Substituted (E)-N′-(1-phenylethylidene)benzohydrazide analogs as histone demethylase inhibitors | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2017-05-09 | — | — | US | disclosed |
| US-9555024-B2 | Substituted (E)-N′-(1-phenylethylidene)benzohydrazide analogs as histone demethylase inhibitors | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2017-01-31 | — | — | US | disclosed |
| US-9555024-B2 | Substituted (E)-N′-(1-phenylethylidene)benzohydrazide analogs as histone demethylase inhibitors | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2017-01-31 | — | — | US | disclosed |
| US-20160120875-A1 | SUBSTITUTED (E)-N'-(1-PHENYLETHYLIDENE)BENZOHYDRAZIDE ANALOGS AS HISTONE DEMETHYLASE INHIBITORS | UNIV UTAH RES FOUND (US) | 2016-05-05 | — | — | US | disclosed |
| US-20160120875-A1 | SUBSTITUTED (E)-N'-(1-PHENYLETHYLIDENE)BENZOHYDRAZIDE ANALOGS AS HISTONE DEMETHYLASE INHIBITORS | UNIV UTAH RES FOUND (US) | 2016-05-05 | — | — | US | disclosed |
| US-9266838-B2 | Substituted (E)-N′-(1-phenylethylidene)benzohydrazide analogs as histone demethylase inhibitors | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2016-02-23 | — | — | US | disclosed |
| US-9266838-B2 | Substituted (E)-N′-(1-phenylethylidene)benzohydrazide analogs as histone demethylase inhibitors | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2016-02-23 | — | — | US | disclosed |
| US-20140163017-A1 | SUBSTITUTED (E)-N'-(1-PHENYLETHYLIDENE)BENZOHYDRAZIDE ANALOGS AS HISTONE DEMETHYLASE INHIBITORS | UNIVERSITY OF UTAH (US) | 2014-06-12 | — | — | US | disclosed |
| WO-2013025805-A1 | SUBSTITUTED (E)-N'-(1-PHENYLETHYLIDENE) BENZOHYDRAZIDE ANALOGS AS HISTONE DEMETHYLASE INHIITORS | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2013-02-21 | — | — | WO | disclosed |
| US-20120010075-A1 | SYNERGISTIC FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER | DOW AGROSCIENCES LLC (US) | 2012-01-12 | — | — | US | disclosed |
| US-20120010075-A1 | SYNERGISTIC FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER | DOW AGROSCIENCES LLC (US) | 2012-01-12 | — | — | US | disclosed |
| US-20100130450-A1 | Methods of Treating Fungal Infections | NORTHEASTERN UNIVERSITY (US) | 2010-05-27 | — | — | US | disclosed |
| US-20100130450-A1 | Methods of Treating Fungal Infections | NORTHEASTERN UNIVERSITY (US) | 2010-05-27 | — | — | US | disclosed |
| US-20100130450-A1 | Methods of Treating Fungal Infections | NORTHEASTERN UNIVERSITY (US) | 2010-05-27 | — | — | US | disclosed |
| EP-2146702-A2 | METHODS OF TREATING FUNGAL INFECTIONS | NorthEastern University (US) | 2010-01-27 | — | — | EP | disclosed |
| WO-2008137128-A2 | METHODS OF TREATING FUNGAL INFECTIONS | NORTHEASTERN UNIVERSITY (US) | 2008-11-13 | — | — | WO | disclosed |
| WO-2008137128-A2 | METHODS OF TREATING FUNGAL INFECTIONS | NORTHEASTERN UNIVERSITY (US) | 2008-11-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120010075-A1 | SYNERGISTIC FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER | SOD1, CYP51A1, SOD3 | KDM1A 484/4885MAOA 509/4885MAOB 811/4885 |
| US-20100130450-A1 | Methods of Treating Fungal Infections | ERG28, DPM1, COXFA4L2 | KDM1A 3517/4885MAOA 726/4885MAOB 819/4885 |
| US-20140163017-A1 | SUBSTITUTED (E)-N'-(1-PHENYLETHYLIDENE)BENZOHYDRAZIDE ANALOGS AS HISTONE DEMETHYLASE INHIBITORS | KDM1B, KDM1A, DOT1L | KDM1A 2/4885MAOA 120/4885MAOB 121/4885 |
| US-20160120875-A1 | SUBSTITUTED (E)-N'-(1-PHENYLETHYLIDENE)BENZOHYDRAZIDE ANALOGS AS HISTONE DEMETHYLASE INHIBITORS | DOT1L, NSD1, KDM1B | KDM1A 7/4885MAOA 1158/4885MAOB 1100/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.