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SCHEMBL6846643

SCHEMBL6846643

CN(C(=O)OC(C)(C)C)C(Cc1ccc2ccccc2c1)C(=O)N(C)C(Cc1ccccc1)C(=O)N(C)N1CCCCC1

nearest known ligand 0.45

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ GHSR Q92847 6/20 0.42
▸ TACR1 P25103 5/20 0.40
▸ CTSB P07858 1/20 0.39
▸ CTSS P25774 1/20 0.39
▸ CTSK P43235 1/20 0.39
▸ PPIA P62937 2/20 0.38
▸ MAOB P27338 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3266848 1.00 GHSR (0.42) GHSRTACR1CTSBCTSSCTSK
SCHEMBL3271144 0.90 REN (0.40) TACR1
SCHEMBL3270415 0.89 GHSR (0.46) GHSRTACR1CTSBCTSSCTSK
SCHEMBL6317705 0.86 GHSR (0.48) GHSRCTSBCTSSCTSKMAOB
SCHEMBL3266843 0.84 GHSR (0.47) GHSRTACR1CTSBCTSSCTSK
SCHEMBL3273825 0.83 GHSR (0.47) GHSRCTSBCTSSCTSKMAOB
SCHEMBL3267715 0.83 GHSR (0.56) GHSRTACR1CTSBCTSSCTSK
SCHEMBL3267721 0.83 GHSR (0.56) GHSRTACR1CTSBCTSSCTSK
SCHEMBL3268068 0.83 GHSR (0.44) GHSRTACR1
SCHEMBL7368069 0.82 GHSR (0.49) GHSRCTSBCTSSCTSKMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1047709-B1 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES NOVO NORDISK AS (DK) 2004-11-03 — — EP disclosed
WO-1999036431-A9 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES NOVO NORDISK AS (DK) 2000-07-27 — — WO disclosed