SCHEMBL68469

SCHEMBL68469

COC(=O)c1sc(C(=O)OC)c(-c2ccccc2)c1-c1ccccc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PLA2G1B P04054 1/20 0.60
ATG4B Q9Y4P1 1/20 0.60
TRPM8 Q7Z2W7 1/20 0.57
LMNA P02545 3/20 0.53
MAPK1 P28482 1/20 0.53
ALDH1A1 P00352 7/20 0.53
MAPT P10636 4/20 0.53
KDM4E B2RXH2 4/20 0.53
HPGD P15428 5/20 0.50
NPSR1 Q6W5P4 2/20 0.50
TSHR P16473 1/20 0.50
GAA P10253 3/20 0.49
KMT2A Q03164 3/20 0.49
MEN1 O00255 2/20 0.49
HSD17B10 Q99714 2/20 0.47
SMN1; SMN2 Q16637 2/20 0.47
GRM6 O15303 1/20 0.47
GRM5 P41594 1/20 0.47
ATM Q13315 2/20 0.47
GLA P06280 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Cyclopropane SCHEMBL11657747 0.90 PLA2G1B (0.52) PLA2G1BATG4BTRPM8LMNAMAPK1
SCHEMBL975593 0.83 LMNA (0.69) PLA2G1BATG4BTRPM8LMNAMAPK1
SCHEMBL10431407 0.83 TRPM8 (0.52) PLA2G1BATG4BTRPM8LMNAMAPK1
SCHEMBL27592419 0.82 ALDH1A1 (0.54) PLA2G1BATG4BTRPM8LMNAMAPK1
SCHEMBL6050721 0.81 FNTA (0.53) ALDH1A1MAPTKDM4EHPGDNPSR1
SCHEMBL10088430 0.81 TRPM8 (0.50) PLA2G1BATG4BTRPM8LMNAMAPK1
SCHEMBL6872798 0.79 TRPM8 (0.51) PLA2G1BATG4BTRPM8LMNAMAPK1
SCHEMBL25203083 0.77 ALDH1A1 (0.53) PLA2G1BATG4BTRPM8LMNAMAPK1
Cyclopropane SCHEMBL11662565 0.77 FNTA (0.50) ALDH1A1MAPTKDM4EHPGDNPSR1
SCHEMBL69825 0.77 GRIA4 (0.50) LMNAALDH1A1MAPTKDM4EHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2479203-A1 AROMATIC POLYESTER Muroran Institute of Technology (JP) 2012-07-25 EP disclosed
US-20120172570-A1 AROMATIC POLYESTER NITTA CORPORATION 2012-07-05 US disclosed
US-8129493-B2 Aromatic polyester MURORAN INSTITUTE OF TECHNOLOGY (JP) 2012-03-06 US disclosed
US-20110224343-A1 MODIFIER FOR AROMATIC POLYESTER AND AROMATIC POLYESTER RESIN COMPOSITION COMPRISING THE SAME MURORAN INSTITUTE OF TECHNOLOGY (JP) 2011-09-15 US disclosed
US-20110092662-A1 AROMATIC POLYESTER NITTA CORPORATION (JP) 2011-04-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110224343-A1 MODIFIER FOR AROMATIC POLYESTER AND AROMATIC POLYESTER RESIN COMPOSITION COMPRISING THE SAME F12, PHAX, WDR82 PLA2G1B 2323/4885ATG4B 1827/4885TRPM8 658/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.