Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | QPCT | Q16769 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 3/20 | 0.33 |
| ▸ | ADH5 | P11766 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.30 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6847872 | 1.00 | QPCT (0.43) | QPCTALDH1A1CYP3A4RECQLCYP1A2 | |
| SCHEMBL6852406 | 0.80 | ENPP2 (0.54) | ALDH1A1CYP3A4KDM4ELMNAMAOB | |
| SCHEMBL6852411 | 0.80 | ENPP2 (0.54) | ALDH1A1CYP3A4KDM4ELMNAMAOB | |
| SCHEMBL9276381 | 0.77 | ALDH1A1 (0.62) | ALDH1A1CYP3A4RECQLCYP1A2CYP2C9 | |
| SCHEMBL9276383 | 0.77 | ALDH1A1 (0.62) | ALDH1A1CYP3A4RECQLCYP1A2CYP2C9 | |
| SCHEMBL7299022 | 0.75 | TBXAS1 (0.42) | ALDH1A1CYP3A4RECQLCYP1A2KDM4E | |
| SCHEMBL7299026 | 0.75 | TBXAS1 (0.42) | ALDH1A1CYP3A4RECQLCYP1A2KDM4E | |
| SCHEMBL6757218 | 0.75 | CYP1A2 (0.44) | QPCTALDH1A1CYP1A2CYP2C9KDM4E | |
| SCHEMBL6852216 | 0.73 | NOTUM (0.50) | ALDH1A1CYP3A4RECQLKDM4EKCNJ1 | |
| SCHEMBL6852221 | 0.73 | NOTUM (0.50) | ALDH1A1CYP3A4RECQLKDM4EKCNJ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6825170-B2 | ERYTHROMYCIN TYPE MACROLIDE WITH A FUSED OXAZOLONE RING | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2004-11-30 | — | — | US | disclosed |
| EP-1453847-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2004-09-08 | — | — | EP | disclosed |
| WO-2003050132-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2003-06-19 | — | — | WO | disclosed |