Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | MELK | Q14680 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6869609 | 0.80 | KDM4E (0.55) | HSP90AA1ALDH1A1KDM4ENPC1GLA | |
| SCHEMBL6847889 | 0.80 | MAPK14 (0.51) | MAPK14MELKDPP4CYP2D6KDM4E | |
| SCHEMBL6847879 | 0.79 | MELK (0.37) | MAPK14MELKDPP4ALDH1A1CYP2D6 | |
| SCHEMBL6854322 | 0.76 | HDAC1 (0.41) | MAPK14MELKDPP4ALDH1A1KDM4E | |
| SCHEMBL6850474 | 0.76 | HSP90AA1 (0.32) | HSP90AA1KDM4ENPC1GLAMAPT | |
| SCHEMBL6852694 | 0.75 | MAPK14 (0.42) | MAPK14MELKALDH1A1CYP2D6 | |
| SCHEMBL6854759 | 0.75 | MAPK14 (0.38) | MAPK14MELKDPP4ALDH1A1CYP2D6 | |
| SCHEMBL6879818 | 0.73 | CYP2A6 (0.56) | MAPK14ALDH1A1CYP2D6 | |
| SCHEMBL4008739 | 0.72 | MAPT (0.48) | MAPK14HSP90AA1ALDH1A1CYP2D6KDM4E | |
| SCHEMBL6854131 | 0.72 | CYP2D6 (0.49) | MAPK14MELKALDH1A1CYP2D6MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6825170-B2 | ERYTHROMYCIN TYPE MACROLIDE WITH A FUSED OXAZOLONE RING | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2004-11-30 | — | — | US | disclosed |
| EP-1453847-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2004-09-08 | — | — | EP | disclosed |
| WO-2003050132-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2003-06-19 | — | — | WO | disclosed |