SCHEMBL6848032

SCHEMBL6848032

CO[Si](C)(OC)c1ccc(N(c2ccc(C)cc2)c2cccc(N(c3ccc(C)cc3)c3ccc(C)cc3)c2)cc1

nearest known ligand 0.35

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
ADRA2A P08913 3/20 0.35
ADRA1A P35348 3/20 0.35
ADRA2B P18089 1/20 0.33
ADRA2C P18825 1/20 0.33
ADRA1D P25100 1/20 0.33
ADRA1B P35368 1/20 0.33
ALDH1A1 P00352 1/20 0.31
TSHR P16473 1/20 0.31
APP P05067 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6851639 0.92 ADRA2A (0.33) ADRA2AADRA1AADRA2BADRA2CADRA1D
SCHEMBL6858715 0.90 ACHE (0.35) ALDH1A1TSHR
SCHEMBL6847974 0.90 ALDH1A1 (0.38) ALDH1A1APP
SCHEMBL6851714 0.90 ALDH1A1 (0.38) ADRA2AADRA1AALDH1A1TSHRAPP
SCHEMBL6843174 0.90 ALDH1A1 (0.38) ADRA2AADRA1AALDH1A1TSHRAPP
SCHEMBL6850575 0.90 ALDH1A1 (0.38) ADRA2AADRA1AALDH1A1TSHRAPP
SCHEMBL6853999 0.90 ALDH1A1 (0.38) ADRA2AADRA1AALDH1A1TSHRAPP
SCHEMBL6850392 0.90 ALDH1A1 (0.38) ALDH1A1TSHR
SCHEMBL6855788 0.90 ALDH1A1 (0.38) ALDH1A1TSHR
SCHEMBL6751376 0.87 ADRA2A (0.35) ADRA2AADRA1AADRA2BADRA2CADRA1D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6696588-B2 OXIDATION POTENTIAL OF .3-1.5 V ON THE BASIS OF A STANDARD HYDROGEN ELECTRODE, ALKOXY AND AROMATIC AMINE DERIVATIVES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2004-02-24 US disclosed
EP-0861845-B1 Silicon-containing compound and organic electroluminescence device using the same SUMITOMO CHEMICAL CO (JP) 2003-05-28 EP disclosed
US-20020115877-A1 Silicon-containing compound and organic electroluminescence device using the same SUMITOMO CHEMICAL COMPANY, LIMITED 2002-08-22 US disclosed
US-6369258-B1 SILICON COMPOUND WITH OXIDATION POTENTIAL ON HYDROGEN ELECTRODE POTENTIAL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2002-04-09 US disclosed
EP-0861845-A2 Silicon-containing compound and organic electroluminescence device using the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1998-09-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020115877-A1 Silicon-containing compound and organic electroluminescence device using the same EPCAM, PIEZO1, OR10J3 ADRA2A 3494/4885ADRA1A 3023/4885ADRA2B 3525/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.