SCHEMBL6848165

SCHEMBL6848165

[CH2]Cc1cccc(-c2ncccn2)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CLK4 Q9HAZ1 5/20 0.47
DYRK1A Q13627 1/20 0.47
ADRB2 P07550 1/20 0.47
CYP2A6 P11509 1/20 0.41
HCRTR1 O43613 6/20 0.39
HCRTR2 O43614 6/20 0.39
PRKCI P41743 1/20 0.39
CETP P11597 1/20 0.36
PRMT6 Q96LA8 1/20 0.36
HRH3 Q9Y5N1 1/20 0.36
CYP19A1 P11511 2/20 0.35
LMNA P02545 2/20 0.35
CYP1A2 P05177 2/20 0.35
CYP3A4 P08684 2/20 0.35
CYP2D6 P10635 2/20 0.35
CYP2C19 P33261 2/20 0.35
MEN1 O00255 1/20 0.35
ALDH1A1 P00352 1/20 0.35
TP53 P04637 1/20 0.35
ALOX15 P16050 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2021727 0.80 CLK4 (0.47) CLK4DYRK1AADRB2CYP2A6HCRTR1
SCHEMBL27706843 0.80 CLK4 (0.47) CLK4DYRK1AADRB2CYP2A6HCRTR1
SCHEMBL20738473 0.80 CLK4 (0.47) CLK4DYRK1AADRB2CYP2A6HCRTR1
SCHEMBL112429 0.80 ADRB2 (0.68) CLK4DYRK1AADRB2CYP2A6
SCHEMBL2130914 0.80 PRKCI (0.61) CLK4DYRK1AADRB2HCRTR1HCRTR2
SCHEMBL29676764 0.80 ADRB2 (0.68) CLK4DYRK1AADRB2CYP2A6
SCHEMBL10162571 0.80 IDO1 (0.53) CLK4DYRK1AADRB2CYP2A6HCRTR1
SCHEMBL3953179 0.79 HRH3 (0.56) CYP2A6HCRTR1HCRTR2CETPHRH3
SCHEMBL9796607 0.79 PTGS2 (0.44) CLK4DYRK1AADRB2CYP2A6HCRTR1
SCHEMBL14961829 0.78 CLK4 (0.61) CLK4DYRK1AADRB2CYP2A6CYP19A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1585775-A 6-O-acyl ketolide derivatives of erythromycine useful as antibacterials ORTHO MCNEIL PHARM INC (US) 2005-02-23 CN disclosed
US-6825170-B2 ERYTHROMYCIN TYPE MACROLIDE WITH A FUSED OXAZOLONE RING ORTHO-MCNEIL PHARMACEUTICAL, INC. 2004-11-30 US disclosed
EP-1453847-A1 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS Ortho-Mcneil Pharmaceutical, Inc. (US) 2004-09-08 EP disclosed
WO-2003050132-A1 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) 2003-06-19 WO disclosed