Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.68 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | CDK8 | P49336 | 1/20 | 0.46 |
| ▸ | PNMT | P11086 | 1/20 | 0.45 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.45 |
| ▸ | LOXL2 | Q9Y4K0 | 5/20 | 0.45 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | NOS3 | P29474 | 2/20 | 0.43 |
| ▸ | NOS1 | P29475 | 2/20 | 0.43 |
| ▸ | NOS2 | P35228 | 2/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.43 |
| ▸ | CFD | P00746 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | LOX | P28300 | 1/20 | 0.42 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.42 |
| ▸ | ATR | Q13535 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL112429 | 1.00 | ADRB2 (0.68) | ADRB2CLK4DYRK1ACDK8PNMT | |
| SCHEMBL14352507 | 0.85 | ADRB2 (0.53) | ADRB2CLK4DYRK1ALOXL2KARS1 | |
| SCHEMBL27928008 | 0.85 | ADRB2 (0.48) | ADRB2CDK8PNMTENPP2LOXL2 | |
| SCHEMBL28237442 | 0.84 | KARS1 (0.54) | ADRB2CLK4CDK8LOXL2KARS1 | |
| SCHEMBL12547520 | 0.82 | MET (0.46) | ADRB2CDK8PNMTENPP2LOXL2 | |
| SCHEMBL13492797 | 0.82 | ADRB2 (0.46) | ADRB2CDK8PNMTENPP2LOXL2 | |
| SCHEMBL1579740 | 0.82 | ADRB2 (0.46) | ADRB2CDK8PNMTENPP2LOXL2 | |
| SCHEMBL2427481 | 0.81 | ADRB2 (1.00) | ADRB2CLK4LOXL2TAAR1CYP2A6 | |
| SCHEMBL3791745 | 0.80 | LOXL2 (0.60) | CDK8PNMTENPP2LOXL2TAAR1 | |
| SCHEMBL6848165 | 0.80 | CLK4 (0.47) | ADRB2CLK4DYRK1ACYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114948963-B | Benzolactam compounds as protein kinase inhibitors | 大冢制药株式会社 | 2025-05-27 | — | — | CN | disclosed |
| CN-114948963-A | Protein kinase inhibitor benzolactam compounds | 大冢制药株式会社 | 2022-08-30 | — | — | CN | disclosed |
| CN-108617166-B | Protein kinase inhibitor benzolactam compounds | 大冢制药株式会社 | 2022-05-17 | — | — | CN | disclosed |