SCHEMBL6848707

SCHEMBL6848707

O=C1C=C(C(=O)O)C(c2ccsc2)CC1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 1/20 0.39
HSD17B10 Q99714 4/20 0.36
ALDH1A1 P00352 3/20 0.36
KDM4E B2RXH2 3/20 0.36
CASP1 P29466 3/20 0.36
GLA P06280 2/20 0.36
GAA P10253 2/20 0.36
HPGD P15428 2/20 0.36
CASP7 P55210 2/20 0.36
LCK P06239 1/20 0.36
FYN P06241 1/20 0.36
DAO P14920 1/20 0.36
HCAR2 Q8TDS4 1/20 0.36
PKM P14618 1/20 0.36
MAPK1 P28482 2/20 0.34
TSHR P16473 1/20 0.34
POLB P06746 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
TP53 P04637 1/20 0.33
ADORA2B P29275 7/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7973421 1.00 CYP19A1 (0.39) CYP19A1HSD17B10ALDH1A1KDM4ECASP1
SCHEMBL7969978 0.80 CTRB1 (0.46) CYP19A1HCAR2POLBTP53
SCHEMBL6844052 0.80 CTRB1 (0.46) CYP19A1HCAR2POLBTP53
SCHEMBL7991029 0.80 CTRB1 (0.46) CYP19A1HCAR2POLBTP53
SCHEMBL6844067 0.73 POLB (0.42) HSD17B10KDM4EGAAHPGDDAO
SCHEMBL7988000 0.73 POLB (0.42) HSD17B10KDM4EGAAHPGDDAO
SCHEMBL7501162 0.66 CYP19A1 (0.45) CYP19A1HSD17B10ALDH1A1KDM4ECASP1
SCHEMBL7969548 0.66 CYP19A1 (0.45) CYP19A1HSD17B10ALDH1A1KDM4ECASP1
SCHEMBL3438177 0.65 CYP19A1 (0.41) CYP19A1ALDH1A1MAPK1POLBSMN1; SMN2
SCHEMBL26746526 0.65 CRBN (0.42) CYP19A1ALDH1A1KDM4EPKMMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1206452-B1 NOVEL METHOD FOR PREPARING BENZOPERHYDROISOINDOLE COMPOUNDS AVENTIS PHARMA SA (FR) 2004-11-03 EP disclosed
EP-1206452-A2 NOVEL METHOD FOR PREPARING BENZOPERHYDROISOINDOLE COMPOUNDS Aventis Pharma S.A. (FR) 2002-05-22 EP disclosed
US-6291679-B1 REACTING 3-OXO-6-PHENYLCYCLOHEX-1-ENE-1-CARBOXYLATE WITH ENZYME FORMING OPTICAL ISOMER; TREATING WITH AMINE PROTECTED N-TRIALKYLSILYLMETHYL-N-(ALKOXYMETHYL)AMINE TO FORM PHENYLPERHYDROISOINDOLE-3A-CARBOXYLATE DERIVATIVE, CYCLIZATION RHONE-POULENC RORER S.A. (FR) 2001-09-18 US disclosed
WO-2001007408-A2 NOVEL METHOD FOR PREPARING BENZOPERHYDROISOINDOLE COMPOUNDS AVENTIS PHARMA S.A. (FR) 2001-02-01 WO disclosed
EP-1042329-A1 NOVEL FARNESYL TRANSFERASE INHIBITORS, PREPARATION, PHARMACEUTICAL, COMPOSITIONS CONTAINING THEM AND USE FOR PREPARING MEDICINES Aventis Pharma S.A. (FR) 2000-10-11 EP disclosed
WO-1999033834-A1 NOVEL FARNESYL TRANSFERASE INHIBITORS, PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND USE FOR PREPARING MEDICINES AVENTIS PHARMA S.A. (FR) 1999-07-08 WO disclosed