Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC25B | P30305 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CDC25A | P30304 | 1/20 | 0.42 |
| ▸ | CDC25C | P30307 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | FNTA | P49354 | 1/20 | 0.40 |
| ▸ | FNTB | P49356 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6842431 | 0.92 | LMNA (0.46) | CDC25BALDH1A1MAPTLMNAHPGD | |
| SCHEMBL6842436 | 0.74 | CDC25B (0.57) | CDC25BALDH1A1MAPTLMNAHPGD | |
| SCHEMBL3606815 | 0.72 | MAPT (0.46) | CDC25BALDH1A1MAPTLMNAHPGD | |
| SCHEMBL6848160 | 0.70 | MAPK8 (0.46) | ALDH1A1MAPTLMNAHPGDSMN1; SMN2 | |
| SCHEMBL3180834 | 0.68 | SLC22A12 (0.47) | CDC25BALDH1A1MAPTLMNAHPGD | |
| SCHEMBL277672 | 0.67 | CDC25B (0.82) | CDC25BALDH1A1MAPTHPGDCDC25A | |
| SCHEMBL15815752 | 0.66 | CYP19A1 (0.48) | CDC25BALDH1A1MAPTLMNAHPGD | |
| SCHEMBL28859320 | 0.66 | PARP1 (0.44) | LMNASMN1; SMN2TDP1KMT2AL3MBTL1 | |
| SCHEMBL28740610 | 0.66 | ALDH1A1 (0.53) | ALDH1A1LMNAHPGDRAB9ASMN1; SMN2 | |
| SCHEMBL4884114 | 0.65 | NPSR1 (0.50) | ALDH1A1MAPTLMNARAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6770646-B2 | PYRROLO-, THIENO-, FURANO-AND PYRAZOLO-(3,4-D)-PYRIDAZINONES; USED FOR TREATING REVERSIBLE OBSTRUCTIVE AIRWAYS DISEASE AND EFFECTING IMMUNOSUPPRESSION | ASTRAZENECA AB (SE) | 2004-08-03 | — | — | US | disclosed |
| EP-1036076-B1 | NOVEL COMPOUNDS | ASTRAZENECA UK LTD (GB) | 2002-09-04 | — | — | EP | disclosed |
| US-20020099055-A1 | Novel compounds | ASTRAZENECA AB. | 2002-07-25 | — | — | US | disclosed |
| US-6342601-B1 | TREATING ALLOGRAFT REJECTION, RHEUMATOID ARTHRITIS | ASTRAZENECA AB (SE) | 2002-01-29 | — | — | US | disclosed |
| EP-1036076-A1 | NOVEL COMPOUNDS | AstraZeneca UK Limited (GB) | 2000-09-20 | — | — | EP | disclosed |
| WO-1999029695-A1 | NOVEL COMPOUNDS | ASTRAZENECA UK LIMITED (GB) | 1999-06-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020099055-A1 | Novel compounds | THPO, CYP4B1, CYP3A4 | CDC25B 1460/4885ALDH1A1 2122/4885MAPT 1404/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.