Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 6/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | CDC25B | P30305 | 2/20 | 0.44 |
| ▸ | CDC25A | P30304 | 1/20 | 0.44 |
| ▸ | CDC25C | P30307 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17225764 | 0.81 | CYP19A1 (0.55) | CYP19A1KMT2ATP53KDM4EMAPK1 | |
| SCHEMBL3180834 | 0.74 | SLC22A12 (0.47) | MAPTALDH1A1KMT2ALMNATP53 | |
| SCHEMBL15897060 | 0.73 | CYP19A1 (0.54) | CYP19A1MAPTALDH1A1HSD17B10KMT2A | |
| SCHEMBL6842436 | 0.72 | CDC25B (0.57) | MAPTALDH1A1KMT2ALMNATP53 | |
| SCHEMBL15937241 | 0.71 | TP53 (0.54) | CYP19A1ALDH1A1KMT2ATP53TSHR | |
| SCHEMBL31124036 | 0.71 | CYP19A1 (0.44) | CYP19A1MAPTKMT2ALMNATP53 | |
| SCHEMBL10463769 | 0.71 | ALDH1A1 (0.54) | MAPTALDH1A1HSD17B10KMT2ALMNA | |
| SCHEMBL6842431 | 0.70 | LMNA (0.46) | MAPTALDH1A1KMT2ALMNAHPGD | |
| SCHEMBL3606815 | 0.70 | MAPT (0.46) | MAPTALDH1A1KMT2ALMNATP53 | |
| SCHEMBL10669971 | 0.69 | ALDH1A1 (0.55) | CYP19A1MAPTALDH1A1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9173892-B2 | Acadesine derivatives, products and compositions including same, therapeutic uses thereof, and methods for synthesizing same | UNIVERSITE NICE SOPHIA ANTIPOLIS (FR) | 2015-11-03 | — | — | US | claimed |
| EP-2699240-B1 | ACADESINE DERIVATIVES, PRODUCTS AND COMPOSITIONS INCLUDING SAME, THERAPEUTIC USES THEREOF, AND METHODS FOR SYNTHESIZING SAME | UNIVERSITÉ NICE SOPHIA ANTIPOLIS (FR) | 2015-05-27 | — | — | EP | claimed |
| US-20140179626-A1 | ACADESINE DERIVATIVES, PRODUCTS AND COMPOSITIONS INCLUDING SAME, THERAPUETIC USES THEREOF, AND METHODS FOR SYNTHESIZING SAME | INSTITUT NATIONAL DE LA SANTE DE LA RECHERCHE MEDICALE (FR) | 2014-06-26 | — | — | US | claimed |
| US-9173892-B2 | Acadesine derivatives, products and compositions including same, therapeutic uses thereof, and methods for synthesizing same | UNIVERSITE NICE SOPHIA ANTIPOLIS (FR) | 2015-11-03 | — | — | US | disclosed |
| US-20150094217-A1 | TEST FOR DIAGNOSING RESISTANCE TO AZACITIDINE | UNIVERSITÉ NICE SOPHIA ANTIPOLIS (FR) | 2015-04-02 | — | — | US | disclosed |
| US-20140179626-A1 | ACADESINE DERIVATIVES, PRODUCTS AND COMPOSITIONS INCLUDING SAME, THERAPUETIC USES THEREOF, AND METHODS FOR SYNTHESIZING SAME | INSTITUT NATIONAL DE LA SANTE DE LA RECHERCHE MEDICALE (FR) | 2014-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140179626-A1 | ACADESINE DERIVATIVES, PRODUCTS AND COMPOSITIONS INCLUDING SAME, THERAPUETIC USES THEREOF, AND METHODS FOR SYNTHESIZING SAME | MCL1, ALOX15, ALOX12 | CYP19A1 1996/4885MAPT 4374/4885ALDH1A1 1038/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.