Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HNF4A | P41235 | 1/20 | 0.69 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.57 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | CNR2 | P34972 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | MYC | P01106 | 1/20 | 0.49 |
| ▸ | LDHA | P00338 | 1/20 | 0.48 |
| ▸ | LDHB | P07195 | 1/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
| ▸ | ALB | P02768 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30361685 | 0.86 | L3MBTL1 (0.59) | HNF4AAKR1C2AKR1C1ALDH1A1KDM4E | |
| SCHEMBL268963 | 0.86 | L3MBTL1 (0.59) | HNF4AAKR1C2AKR1C1ALDH1A1KDM4E | |
| SCHEMBL16247702 | 0.86 | AKR1C2 (0.65) | HNF4AAKR1C2AKR1C1ALDH1A1HPGD | |
| SCHEMBL16247703 | 0.85 | AKR1C2 (0.51) | HNF4AAKR1C2AKR1C1ALDH1A1HPGD | |
| SCHEMBL2533619 | 0.83 | HNF4A (0.79) | HNF4AAKR1C2AKR1C1ALDH1A1L3MBTL1 | |
| SCHEMBL73041 | 0.82 | HNF4A (1.00) | HNF4AAKR1C2AKR1C1ALDH1A1KDM4E | |
| SCHEMBL29662951 | 0.82 | HNF4A (1.00) | HNF4AAKR1C2AKR1C1ALDH1A1KDM4E | |
| SCHEMBL388293 | 0.81 | NR1H4 (0.59) | HNF4AAKR1C2AKR1C1ALDH1A1KDM4E | |
| SCHEMBL5964729 | 0.80 | HNF4A (0.96) | HNF4AAKR1C2AKR1C1ALDH1A1KDM4E | |
| SCHEMBL28302531 | 0.80 | HNF4A (0.96) | HNF4AAKR1C2AKR1C1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9238637-B2 | Stable polymorphic forms of compound as hypoxia mimetics, and uses thereof | BEIJING BETTA PHARMACEUTICALS CO., LTD (CN) | 2016-01-19 | — | — | US | disclosed |
| US-9238637-B2 | Stable polymorphic forms of compound as hypoxia mimetics, and uses thereof | BEIJING BETTA PHARMACEUTICALS CO., LTD (CN) | 2016-01-19 | — | — | US | disclosed |
| US-20140343137-A1 | Stable Polymorphic Forms of Compound as Hypoxia Mimetics, and Uses Thereof | BEIJING BETTA PHARMACEUTICALS CO., LTD. (CN) | 2014-11-20 | — | — | US | disclosed |
| US-20140343137-A1 | Stable Polymorphic Forms of Compound as Hypoxia Mimetics, and Uses Thereof | BEIJING BETTA PHARMACEUTICALS CO., LTD. (CN) | 2014-11-20 | — | — | US | disclosed |
| EP-1294378-A4 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORP (US) | 2004-01-28 | — | — | EP | disclosed |
| EP-1294378-A2 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-03-26 | — | — | EP | disclosed |
| WO-2001089457-A2 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-11-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140343137-A1 | Stable Polymorphic Forms of Compound as Hypoxia Mimetics, and Uses Thereof | HIF1A, HIF1AN, COXFA4L2 | HNF4A 749/4885AKR1C2 497/4885AKR1C1 594/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.