Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | APAF1 | O14727 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 6/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.34 |
| ▸ | TLR4 | O00206 | 1/20 | 0.34 |
| ▸ | TLR2 | O60603 | 1/20 | 0.34 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6850805 | 1.00 | LMNA (0.54) | LMNASMN1; SMN2ALDH1A1KDM4EMEN1 | |
| SCHEMBL6850795 | 1.00 | LMNA (0.54) | LMNASMN1; SMN2ALDH1A1KDM4EMEN1 | |
| SCHEMBL6851841 | 0.81 | SMN1; SMN2 (0.57) | LMNASMN1; SMN2ALDH1A1KDM4EMEN1 | |
| SCHEMBL6851837 | 0.81 | SMN1; SMN2 (0.57) | LMNASMN1; SMN2ALDH1A1KDM4EMEN1 | |
| SCHEMBL6276439 | 0.76 | ADRB2 (0.42) | MEN1KMT2ARAB9ANPC1AOC3 | |
| SCHEMBL6879073 | 0.76 | ADRB2 (0.42) | MEN1KMT2ARAB9ANPC1AOC3 | |
| SCHEMBL6309957 | 0.76 | ADRB2 (0.42) | MEN1KMT2ARAB9ANPC1AOC3 | |
| SCHEMBL6850762 | 0.74 | ALDH1A1 (0.57) | LMNASMN1; SMN2ALDH1A1KDM4EMEN1 | |
| SCHEMBL6850767 | 0.74 | ALDH1A1 (0.57) | LMNASMN1; SMN2ALDH1A1KDM4EMEN1 | |
| SCHEMBL4630813 | 0.73 | ALDH1A1 (0.53) | LMNAALDH1A1KDM4EMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6825170-B2 | ERYTHROMYCIN TYPE MACROLIDE WITH A FUSED OXAZOLONE RING | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2004-11-30 | — | — | US | disclosed |
| EP-1453847-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2004-09-08 | — | — | EP | disclosed |
| WO-2003050132-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2003-06-19 | — | — | WO | disclosed |