Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | APAF1 | O14727 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 6/20 | 0.42 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | TLR4 | O00206 | 1/20 | 0.38 |
| ▸ | TLR2 | O60603 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6850762 | 1.00 | ALDH1A1 (0.57) | ALDH1A1LMNASMN1; SMN2KDM4EMEN1 | |
| SCHEMBL10949485 | 0.79 | LTA4H (0.52) | ALDH1A1LMNAMEN1KMT2ARAB9A | |
| SCHEMBL10949490 | 0.79 | LTA4H (0.52) | ALDH1A1LMNAMEN1KMT2ARAB9A | |
| SCHEMBL6852485 | 0.77 | SMN1; SMN2 (0.62) | ALDH1A1LMNASMN1; SMN2KDM4EMEN1 | |
| SCHEMBL6879792 | 0.75 | LMNA (0.69) | ALDH1A1LMNASMN1; SMN2KDM4EMEN1 | |
| SCHEMBL6879797 | 0.75 | LMNA (0.69) | ALDH1A1LMNASMN1; SMN2KDM4EMEN1 | |
| SCHEMBL6850802 | 0.74 | LMNA (0.54) | ALDH1A1LMNASMN1; SMN2KDM4EMEN1 | |
| SCHEMBL6850795 | 0.74 | LMNA (0.54) | ALDH1A1LMNASMN1; SMN2KDM4EMEN1 | |
| SCHEMBL6850805 | 0.74 | LMNA (0.54) | ALDH1A1LMNASMN1; SMN2KDM4EMEN1 | |
| SCHEMBL6228721 | 0.74 | ADRB2 (0.44) | ALDH1A1MEN1KMT2ARAB9ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6825170-B2 | ERYTHROMYCIN TYPE MACROLIDE WITH A FUSED OXAZOLONE RING | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2004-11-30 | — | — | US | disclosed |
| EP-1453847-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2004-09-08 | — | — | EP | disclosed |
| WO-2003050132-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2003-06-19 | — | — | WO | disclosed |