Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | PRCP | P42785 | 2/20 | 0.37 |
| ▸ | LIPE | Q05469 | 4/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6410109 | 0.92 | MEN1 (0.45) | OPRM1OPRD1MEN1KMT2ACRHBP | |
| SCHEMBL6410158 | 0.91 | OPRM1 (0.43) | OPRM1OPRD1MEN1KMT2ACRHBP | |
| SCHEMBL6409491 | 0.81 | CRHBP (0.48) | OPRM1OPRD1MEN1KMT2ACRHBP | |
| SCHEMBL2405022 | 0.81 | MEN1 (0.46) | OPRM1OPRD1MEN1KMT2ACRHBP | |
| SCHEMBL2404639 | 0.78 | OPRM1 (0.47) | OPRM1OPRD1MEN1KMT2ACRHBP | |
| SCHEMBL6411587 | 0.76 | HSD17B10 (0.48) | KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL6412295 | 0.75 | MEN1 (0.52) | MEN1KMT2APRCPLIPEALDH1A1 | |
| SCHEMBL6410676 | 0.74 | MEN1 (0.41) | MEN1KMT2APRCPLIPECHRM5 | |
| SCHEMBL6410287 | 0.74 | HSD17B10 (0.45) | MEN1KMT2ACRHBPCRHR2CHRM5 | |
| SCHEMBL6417412 | 0.73 | ATM (0.51) | KMT2AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1401841-A1 | SUBSTITUTED 1-OXA-2,8-DIAZA-SPIRO 4,5]DEC-2-ENE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF PAIN | Grünenthal GmbH (DE) | 2004-03-31 | — | — | EP | claimed |
| WO-2003000699-A1 | SUBSTITUTED 1-OXA-2,8-DIAZA-SPIRO[4,5]DEC-2-ENE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF PAIN | Grünenthal GmbH (DE) | 2003-01-03 | — | — | WO | claimed |