Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6412249 | 0.87 | JAK2 (0.43) | ALDH1A1L3MBTL1KMT2ASMN1; SMN2GAA | |
| SCHEMBL6410302 | 0.86 | SMN1; SMN2 (0.58) | ATMMAPTALDH1A1TSHRL3MBTL1 | |
| SCHEMBL6409831 | 0.85 | ATM (0.55) | ATMMAPTALDH1A1ALOX15TSHR | |
| SCHEMBL6410504 | 0.82 | MEN1 (0.49) | MAPTALDH1A1TSHRL3MBTL1USP2 | |
| SCHEMBL6410158 | 0.81 | OPRM1 (0.43) | ATMMAPTALDH1A1ALOX15TSHR | |
| SCHEMBL6417720 | 0.80 | ALDH1A1 (0.58) | ALDH1A1ALOX15TSHRL3MBTL1USP2 | |
| SCHEMBL6411079 | 0.80 | LMNA (0.44) | MAPTALDH1A1TSHRL3MBTL1KMT2A | |
| SCHEMBL6411317 | 0.79 | TP53 (0.41) | ATMMAPTALDH1A1CNR1KMT2A | |
| SCHEMBL6410171 | 0.79 | L3MBTL1 (0.44) | MAPTALDH1A1L3MBTL1KMT2AKDM4E | |
| SCHEMBL6410069 | 0.78 | TDP1 (0.42) | ATMMAPTALDH1A1USP2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1401841-B1 | SUBSTITUTED 1-OXA-2,8-DIAZA-SPIRO 4,5]DEC-2-ENE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF PAIN | GRUENENTHAL GMBH (DE) | 2005-08-24 | — | — | EP | disclosed |