Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 2/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 2/20 | 0.34 |
| ▸ | EP300 | Q09472 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.33 |
| ▸ | WNT3A | P56704 | 5/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6277380 | 0.81 | HDAC4 (0.40) | HDAC4DHODHGABRA1GABRG2GABRB3 | |
| SCHEMBL6852198 | 0.78 | HDAC4 (0.39) | HDAC4DHODHGABRA1GABRG2GABRB3 | |
| SCHEMBL6876005 | 0.78 | HDAC4 (0.39) | HDAC4DHODHGABRA1GABRG2GABRB3 | |
| SCHEMBL2551622 | 0.78 | HDAC4 (0.43) | HDAC4DHODHGABRA1GABRG2GABRB3 | |
| SCHEMBL6847888 | 0.76 | CYP1A2 (0.47) | DHODHGRM5 | |
| SCHEMBL6850679 | 0.75 | HDAC4 (0.43) | HDAC4DHODHGABRA1GABRG2GABRB3 | |
| SCHEMBL13458062 | 0.72 | GABRA1 (0.52) | HDAC4DHODHGABRA1GABRG2GABRB3 | |
| SCHEMBL29959678 | 0.72 | RAB9A (0.50) | HDAC4DHODHGABRA1GABRG2GABRB3 | |
| SCHEMBL121970 | 0.72 | RAB9A (0.50) | HDAC4DHODHGABRA1GABRG2GABRB3 | |
| SCHEMBL6852799 | 0.71 | NPC1 (0.33) | GRM5EP300SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1585775-A | 6-O-acyl ketolide derivatives of erythromycine useful as antibacterials | ORTHO MCNEIL PHARM INC (US) | 2005-02-23 | — | — | CN | disclosed |
| US-6825170-B2 | ERYTHROMYCIN TYPE MACROLIDE WITH A FUSED OXAZOLONE RING | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2004-11-30 | — | — | US | disclosed |
| EP-1453847-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2004-09-08 | — | — | EP | disclosed |
| WO-2003050132-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2003-06-19 | — | — | WO | disclosed |