Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 2/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | MELK | Q14680 | 1/20 | 0.39 |
| ▸ | EP300 | Q09472 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP12 | P39900 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.34 |
| ▸ | WNT3A | P56704 | 4/20 | 0.33 |
| ▸ | ITK | Q08881 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.32 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | GABRP | O00591 | 1/20 | 0.32 |
| ▸ | GABRD | O14764 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6854186 | 0.79 | CYP1A2 (0.47) | DHODHMELKMMP2MMP12ALDH1A1 | |
| SCHEMBL6851865 | 0.78 | HDAC4 (0.38) | HDAC4DHODHEP300PRMT5WDR77 | |
| SCHEMBL2551622 | 0.78 | HDAC4 (0.43) | HDAC4DHODHEP300PRMT5WDR77 | |
| SCHEMBL6852567 | 0.74 | MMP2 (0.36) | MELKEP300MMP2MMP12ALDH1A1 | |
| SCHEMBL6852198 | 0.74 | HDAC4 (0.39) | HDAC4DHODHEP300PRMT5WDR77 | |
| SCHEMBL9672111 | 0.74 | MMP2 (0.50) | MELKMMP2MMP12ALDH1A1GABRA1 | |
| SCHEMBL6215593 | 0.74 | MKNK1 (0.50) | HDAC4DHODHEP300PRMT5WDR77 | |
| SCHEMBL6277380 | 0.74 | HDAC4 (0.40) | HDAC4DHODHEP300PRMT5WDR77 | |
| SCHEMBL6227667 | 0.73 | ALDH1A1 (0.46) | MELKMMP2MMP12ALDH1A1ITK | |
| SCHEMBL6854314 | 0.72 | MKNK1 (0.57) | MELKALDH1A1CYP2A6CYP2C9CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6825170-B2 | ERYTHROMYCIN TYPE MACROLIDE WITH A FUSED OXAZOLONE RING | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2004-11-30 | — | — | US | disclosed |