Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 2/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | EP300 | Q09472 | 2/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.32 |
| ▸ | WNT3A | P56704 | 3/20 | 0.32 |
| ▸ | GOT1 | P17174 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6851865 | 0.81 | HDAC4 (0.38) | HDAC4DHODHGABRA1GABRG2GABRB3 | |
| SCHEMBL2551622 | 0.81 | HDAC4 (0.43) | HDAC4DHODHGABRA1GABRG2GABRB3 | |
| SCHEMBL6850679 | 0.78 | HDAC4 (0.43) | HDAC4DHODHGABRA1GABRG2GABRB3 | |
| SCHEMBL13458062 | 0.75 | GABRA1 (0.52) | HDAC4DHODHGABRA1GABRG2GABRB3 | |
| SCHEMBL121970 | 0.74 | RAB9A (0.50) | HDAC4DHODHGABRA1GABRG2GABRB3 | |
| SCHEMBL29959678 | 0.74 | RAB9A (0.50) | HDAC4DHODHGABRA1GABRG2GABRB3 | |
| SCHEMBL6852198 | 0.74 | HDAC4 (0.39) | HDAC4DHODHGABRA1GABRG2GABRB3 | |
| SCHEMBL6876005 | 0.74 | HDAC4 (0.39) | HDAC4DHODHGABRA1GABRG2GABRB3 | |
| SCHEMBL218007 | 0.74 | L3MBTL1 (0.49) | HDAC4DHODHGRM5EP300SLC6A2 | |
| SCHEMBL6850684 | 0.74 | SLC6A2 (0.49) | HDAC4DHODHSLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005121160-A2 | 11, 12 CYCLIC THIOCARBAMATE MACROLIDE ANTIBACTERIAL AGENTS | JOHNSON & JOHNSON PHARMACEUTICAL RESEARCH & DEVELOPMENT (US) | 2005-12-22 | — | — | WO | disclosed |
| US-20050250713-A1 | 11,12-Cyclic thiocarbamate macrolide antibacterial agents | ZHU BIN | 2005-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050250713-A1 | 11,12-Cyclic thiocarbamate macrolide antibacterial agents | MRPL21, TTC14, MRPL12 | HDAC4 526/4885DHODH 3119/4885GABRA1 3857/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.