Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28579116 | 0.82 | LMNA (0.34) | THRBTDP1LMNA | |
| SCHEMBL28538107 | 0.82 | LMNA (0.34) | THRBTDP1LMNA | |
| SCHEMBL27619437 | 0.81 | THRB (0.33) | THRBTDP1LMNA | |
| SCHEMBL27999803 | 0.81 | THRB (0.33) | THRBTDP1LMNA | |
| SCHEMBL28716007 | 0.80 | MMP3 (0.31) | — | |
| SCHEMBL23748573 | 0.77 | SMYD3 (0.32) | LMNA | |
| SCHEMBL28874371 | 0.77 | HTT (0.34) | — | |
| SCHEMBL11418958 | 0.75 | MAOB (0.33) | — | |
| SCHEMBL27503377 | 0.73 | MAOB (0.34) | — | |
| SCHEMBL28438018 | 0.71 | LMNA (0.36) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1294378-A4 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORP (US) | 2004-01-28 | — | — | EP | disclosed |
| EP-1294378-A2 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-03-26 | — | — | EP | disclosed |
| WO-2001089457-A2 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-11-29 | — | — | WO | disclosed |