Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6228672 | 0.66 | — | — | |
| SCHEMBL6089366 | 0.64 | PARP1 (0.35) | — | |
| SCHEMBL2174440 | 0.63 | HTR2C (0.43) | MAOAMAOB | |
| SCHEMBL28547192 | 0.63 | — | — | |
| SCHEMBL3333311 | 0.61 | HTR2C (0.46) | — | |
| SCHEMBL9129097 | 0.61 | — | — | |
| SCHEMBL30322772 | 0.60 | MAOA (0.47) | MAOAMAOB | |
| SCHEMBL2239784 | 0.60 | MAOA (0.47) | MAOAMAOB | |
| SCHEMBL14452876 | 0.60 | SIGMAR1 (0.48) | PDE3BPDE3AMAOAMAOB | |
| SCHEMBL29699898 | 0.60 | SIGMAR1 (0.48) | PDE3BPDE3AMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6777406-B2 | SUCH AS PYRIDO(3,2,1-IJ)PYRROLO(3,4-C)QUINOLIN-8-ONE DERI-VATIVES; CENTRAL NERVOUS SYSTEM DISORDERS; GASTROINTESTINAL DISORDERS | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2004-08-17 | — | — | US | disclosed |