Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.69 |
| ▸ | NPC1 | O15118 | 5/20 | 0.69 |
| ▸ | RAB9A | P51151 | 5/20 | 0.69 |
| ▸ | PPARG | P37231 | 1/20 | 0.67 |
| ▸ | PPARA | Q07869 | 1/20 | 0.67 |
| ▸ | KCNK3 | O14649 | 3/20 | 0.66 |
| ▸ | KCNK9 | Q9NPC2 | 3/20 | 0.66 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.66 |
| ▸ | PKM | P14618 | 1/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6853295 | 0.88 | KMT2A (0.66) | NR1H4KMT2ANPC1RAB9APPARG | |
| SCHEMBL3996735 | 0.88 | KMT2A (0.66) | NR1H4KMT2ANPC1RAB9APPARG | |
| SCHEMBL6859800 | 0.86 | MAPT (0.64) | NR1H4KMT2ANPC1RAB9AKCNK3 | |
| SCHEMBL11593167 | 0.85 | KMT2A (0.76) | NR1H4KMT2ANPC1RAB9AKCNK3 | |
| SCHEMBL28622654 | 0.85 | RAB9A (0.93) | KMT2ANPC1RAB9AKCNK3KCNK9 | |
| SCHEMBL6251549 | 0.83 | NR1H4 (0.63) | NR1H4KMT2ANPC1RAB9APPARG | |
| SCHEMBL27550517 | 0.83 | KMT2A (0.70) | NR1H4KMT2ANPC1RAB9AKCNK3 | |
| SCHEMBL2501251 | 0.82 | LCK (0.72) | KMT2ARAB9AKCNK3KCNK9MEN1 | |
| SCHEMBL1129948 | 0.82 | KMT2A (0.77) | NR1H4KMT2ANPC1RAB9AKCNK3 | |
| SCHEMBL6778190 | 0.82 | KMT2A (0.71) | KMT2ANPC1RAB9AKCNK3KCNK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6794380-B2 | ANTIINFLAMMATORY AGENTS; AUTOIMMUNE DISEASE; ANTIALLERGENS | ASTRAZENECA AB (SE) | 2004-09-21 | — | — | US | disclosed |
| US-20030186966-A1 | Amide derivatives | ASTRAZENECA AB | 2003-10-02 | — | — | US | disclosed |
| US-6548514-B1 | Inhibitors of p38 kinase/cytokine suppressive binding protein (CSBP)/reactivating kinase (RK); 1-((pyridyl)aminocarbonyl)-3-((hetero)arylaminocarbonyl)benzene derivatives; treating cytokine related diseases and disorders | ASTRAZENECA AB (SE) | 2003-04-15 | — | — | US | disclosed |
| EP-1163212-A1 | AMIDE DERIVATIVES | AstraZeneca AB (SE) | 2001-12-19 | — | — | EP | disclosed |
| WO-2000055120-A1 | AMIDE DERIVATIVES | ASTRAZENECA AB (SE) | 2000-09-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030186966-A1 | Amide derivatives | IL6, IL6ST, IFNG | NR1H4 697/4885KMT2A 2495/4885NPC1 599/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.