SCHEMBL685373

SCHEMBL685373

COc1ccc(C(=O)N/N=C(\C)c2cc(F)cc(F)c2O)cc1

nearest known ligand 0.59

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
MAPT P10636 9/20 0.56
CYP1A2 P05177 1/20 0.56
NPC1 O15118 7/20 0.55
GAA P10253 3/20 0.54
RAB9A P51151 8/20 0.52
SMN1; SMN2 Q16637 6/20 0.52
ALDH1A1 P00352 5/20 0.48
MIF P14174 1/20 0.48
PSMD14 O00487 1/20 0.48
HPGD P15428 1/20 0.48
KDM4E B2RXH2 4/20 0.48
LMNA P02545 1/20 0.46
POLB P06746 1/20 0.46
MAPK1 P28482 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL685106 0.86 MAPT (0.54) MAPTNPC1GAARAB9ASMN1; SMN2
SCHEMBL684742 0.85 KDM1A (0.54) MAPTCYP1A2NPC1GAARAB9A
SCHEMBL685375 0.85 RAB9A (0.54) MAPTCYP1A2NPC1GAARAB9A
SCHEMBL684732 0.85 NPC1 (0.67) MAPTCYP1A2NPC1GAARAB9A
SCHEMBL684913 0.84 MTOR (0.53) MAPTCYP1A2NPC1GAARAB9A
SCHEMBL685326 0.79 MAPT (0.61) MAPTCYP1A2NPC1GAARAB9A
SCHEMBL684717 0.79 GAA (0.54) MAPTCYP1A2NPC1GAARAB9A
SCHEMBL685324 0.79 GAA (0.54) MAPTCYP1A2NPC1GAARAB9A
SCHEMBL684088 0.79 MTOR (0.55) MAPTCYP1A2NPC1GAARAB9A
SCHEMBL684092 0.78 KDM1A (0.54) MAPTCYP1A2NPC1GAARAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8476194-B2 Fungicidal compositions including hydrazone derivatives and copper DOW AGROSCIENCES, LLC (US) 2013-07-02 US disclosed
US-8476194-B2 Fungicidal compositions including hydrazone derivatives and copper DOW AGROSCIENCES, LLC (US) 2013-07-02 US disclosed
US-20120021066-A1 FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-01-26 US disclosed
US-20120021066-A1 FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-01-26 US disclosed
US-20120010075-A1 SYNERGISTIC FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-01-12 US disclosed
US-20120010075-A1 SYNERGISTIC FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-01-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120010075-A1 SYNERGISTIC FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER SOD1, CYP51A1, SOD3 MAPT 1491/4885CYP1A2 11/4885NPC1 1690/4885
US-20120021066-A1 FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER SOD1, CYP51A1, CYP4Z1 MAPT 921/4885CYP1A2 12/4885NPC1 1052/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.