Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 2/20 | 0.44 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | EDNRB | P24530 | 1/20 | 0.38 |
| ▸ | EDNRA | P25101 | 1/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.37 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 2/20 | 0.37 |
| ▸ | SRC | P12931 | 2/20 | 0.37 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6266827 | 0.85 | MMP13 (0.45) | MMP13SLC22A8KDM4EALDH1A1HPGD | |
| SCHEMBL6450474 | 0.74 | MMP13 (0.36) | MMP13SLC22A8KDM4EALDH1A1PTGER4 | |
| SCHEMBL6270125 | 0.67 | ERCC5 (0.46) | MMP13SLC22A8KDM4EALDH1A1LMNA | |
| SCHEMBL7022321 | 0.67 | MMP13 (0.55) | MMP13SLC22A8ALDH1A1HPGDLMNA | |
| SCHEMBL29240206 | 0.65 | VKORC1 (0.44) | KDM4EALDH1A1HPGDLMNAHSD17B10 | |
| SCHEMBL30866031 | 0.65 | VKORC1 (0.44) | KDM4EALDH1A1HPGDLMNAHSD17B10 | |
| SCHEMBL6270126 | 0.64 | MMP13 (0.44) | MMP13SLC22A8ALDH1A1PTGER4MEN1 | |
| SCHEMBL30866020 | 0.64 | KDM4E (0.50) | KDM4EALDH1A1HPGDLMNAHSD17B10 | |
| SCHEMBL29240178 | 0.64 | KDM4E (0.50) | KDM4EALDH1A1HPGDLMNAHSD17B10 | |
| SCHEMBL7013269 | 0.63 | MMP13 (0.58) | MMP13SLC22A8KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040034086-A1 | Combination of an allosteric inhibitor of matrix metalloproteinase-13 with celecoxib or valdecoxib | ROARK WILLIAM HOWARD (US) | 2004-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040034086-A1 | Combination of an allosteric inhibitor of matrix metalloproteinase-13 with celecoxib or valdecoxib | MMP11, MMP13, MMP10 | MMP13 2/4885SLC22A8 255/4885KDM4E 537/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.