Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | VCP | P55072 | 1/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.35 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.32 |
| ▸ | PI4KA | P42356 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6847737 | 0.79 | HDAC4 (0.35) | NPC1RAB9AHDAC4NFKB1NFKB2 | |
| SCHEMBL6848088 | 0.79 | ADRB2 (0.44) | CLK4ADRB2CYP2A6VCPAOC3 | |
| SCHEMBL6847888 | 0.79 | CYP1A2 (0.47) | CYP2A6CYP1A2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6854125 | 0.78 | MEN1 (0.38) | CYP1A2NPC1RAB9ACYP3A4SMN1; SMN2 | |
| SCHEMBL6685962 | 0.76 | CLK4 (0.64) | CLK4ADRB2CYP2A6AOC3CYP1A2 | |
| SCHEMBL20985726 | 0.76 | CLK4 (0.46) | CLK4ADRB2CYP2A6VCPAOC3 | |
| SCHEMBL6852057 | 0.76 | ADRB2 (0.42) | CLK4ADRB2CYP2A6VCPAOC3 | |
| SCHEMBL6227667 | 0.75 | ALDH1A1 (0.46) | CLK4ADRB2CYP2A6VCPAOC3 | |
| SCHEMBL6852190 | 0.75 | CLK4 (0.40) | CLK4ADRB2CYP2A6VCPAOC3 | |
| SCHEMBL6847895 | 0.75 | NPC1 (0.40) | CLK4CYP2A6CYP1A1CYP1A2CYP1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1585775-A | 6-O-acyl ketolide derivatives of erythromycine useful as antibacterials | ORTHO MCNEIL PHARM INC (US) | 2005-02-23 | — | — | CN | disclosed |
| US-6825170-B2 | ERYTHROMYCIN TYPE MACROLIDE WITH A FUSED OXAZOLONE RING | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2004-11-30 | — | — | US | disclosed |
| EP-1453847-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2004-09-08 | — | — | EP | disclosed |
| WO-2003050132-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2003-06-19 | — | — | WO | disclosed |