Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.34 |
| ▸ | NPC1 | O15118 | 4/20 | 0.34 |
| ▸ | RAB9A | P51151 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | APLNR | P35414 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | HPGD | P15428 | 4/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.31 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.31 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.31 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6854227 | 1.00 | ALDH1A1 (0.39) | ALDH1A1CYP3A4RECQLSMN1; SMN2NPC1 | |
| SCHEMBL6852515 | 0.81 | LMNA (0.40) | ALDH1A1CYP3A4RECQLSMN1; SMN2NPC1 | |
| SCHEMBL6852522 | 0.81 | LMNA (0.40) | ALDH1A1CYP3A4RECQLSMN1; SMN2NPC1 | |
| SCHEMBL6852317 | 0.78 | APLNR (0.36) | CYP3A4SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL17051575 | 0.76 | NPC1 (0.44) | ALDH1A1SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL6851881 | 0.75 | HDAC4 (0.43) | ALDH1A1CYP3A4RECQLP2RX7 | |
| SCHEMBL6851894 | 0.75 | HDAC4 (0.43) | ALDH1A1CYP3A4RECQLP2RX7 | |
| SCHEMBL12970083 | 0.74 | FYN (0.41) | SMN1; SMN2NPC1RAB9ALMNANFKB1 | |
| SCHEMBL26018390 | 0.74 | KDM4E (0.33) | ALDH1A1SMN1; SMN2NPC1RAB9AAPLNR | |
| SCHEMBL7029497 | 0.72 | GPR119 (0.34) | ALDH1A1SMN1; SMN2NPC1RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1453847-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2004-09-08 | — | — | EP | disclosed |
| WO-2003050132-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2003-06-19 | — | — | WO | disclosed |