Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 19/20 | 0.57 |
| ▸ | THRA | P10827 | 17/20 | 0.57 |
| ▸ | PCNA | P12004 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6852998 | 0.90 | THRB (0.57) | THRBTHRA | |
| SCHEMBL6853030 | 0.88 | THRB (0.57) | THRBTHRAPCNAPOLBMAPK1 | |
| SCHEMBL6854434 | 0.86 | THRA (0.48) | THRBTHRAPCNAPOLBMAPK1 | |
| SCHEMBL6855018 | 0.82 | THRB (0.48) | THRBTHRAPCNAPOLBMAPK1 | |
| SCHEMBL6738832 | 0.80 | THRA (0.43) | THRBTHRA | |
| SCHEMBL6852972 | 0.78 | THRB (0.60) | THRBTHRAPCNAPOLBMAPK1 | |
| SCHEMBL6852856 | 0.78 | THRA (0.49) | THRBTHRAPCNAPOLBMAPK1 | |
| SCHEMBL6853009 | 0.77 | THRA (0.45) | THRBTHRAPCNAPOLBHIF1A | |
| SCHEMBL6854363 | 0.77 | THRB (0.58) | THRBTHRA | |
| SCHEMBL6854527 | 0.77 | THRA (0.45) | THRBTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6777442-B2 | Diphenyl derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 2004-08-17 | — | — | US | disclosed |
| US-20030105078-A1 | Diphenyl derivatives | BAYER AKTIENGESSELLSCHAFT (DE) | 2003-06-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030105078-A1 | Diphenyl derivatives | DPP4, DPP3, DPM1 | THRB 4614/4885THRA 4665/4885PCNA 2040/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.