Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.35 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.35 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6856386 | 1.00 | SMN1; SMN2 (0.39) | SMN1; SMN2CYP3A4LMNAPOLBMAPT | |
| SCHEMBL6854340 | 0.99 | POLB (0.40) | SMN1; SMN2CYP3A4LMNAPOLBMAPT | |
| SCHEMBL6856146 | 0.83 | CYP3A4 (0.37) | SMN1; SMN2CYP3A4LMNAPOLBMAPT | |
| SCHEMBL5370048 | 0.80 | LMNA (0.43) | CYP3A4LMNAPKMKDM4ECYP2C19 | |
| SCHEMBL6856741 | 0.80 | SMN1; SMN2 (0.41) | SMN1; SMN2CYP3A4LMNAPKMNPC1 | |
| SCHEMBL6856652 | 0.80 | SMN1; SMN2 (0.41) | SMN1; SMN2CYP3A4LMNAPKMNPC1 | |
| SCHEMBL6856654 | 0.78 | CYP3A4 (0.39) | SMN1; SMN2CYP3A4LMNAPKMALDH1A1 | |
| SCHEMBL28813252 | 0.73 | ALDH1A1 (0.46) | SMN1; SMN2NPC1ALDH1A1RAB9AKDM4E | |
| SCHEMBL23356707 | 0.70 | GSK3B (0.40) | SMN1; SMN2CYP3A4LMNAPKMALDH1A1 | |
| SCHEMBL30693376 | 0.70 | GSK3B (0.40) | SMN1; SMN2CYP3A4LMNAPKMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6828332-B1 | Antagonists and partial agonists of the serotonin receptor, and activity as inhibitors of serotonin reuptake for treatment of depression | ELI LILLY AND COMPANY | 2004-12-07 | — | — | US | disclosed |
| US-6664274-B1 | 4-(4-benzothiophene- or 4-benzofuran-1,2,3,6-tetrahydro-pyridyl)- derivatives; 5-HT1A and 5-HT2A receptor antagonists; tobacco or nicotine withdrawal | ELI LILLY AND COMPANY | 2003-12-16 | — | — | US | disclosed |
| US-20020193590-A1 | Azepine derivatives having effects on serotonin related systems | HAUSER KENNETH LEE (US) | 2002-12-19 | — | — | US | disclosed |
| EP-1091741-A4 | AZEPINE DERIVATIVES HAVING EFFECTS ON SEROTONIN RELATED SYSTEMS | LILLY CO ELI (US) | 2002-12-18 | — | — | EP | disclosed |
| EP-1100501-A4 | PYRROLIDINE AND PYRROLINE DERIVATIVES HAVING EFFECTS ON SEROTONIN RELATED SYSTEMS | LILLY CO ELI (US) | 2002-12-04 | — | — | EP | disclosed |
| US-6465453-B1 | INHIBITING REUPTAKE OF SEROTONIN; ANTAGONIZING 5-HT-1A AND 2A RECEPTORS; TOBACCO OR NICOTINE WITHDRAWAL, ANXIETY, SLEEP DISORDERS, DEPRESSION, HYPERTENSION, COGNITIVE DISORDERS, PSYCHOSIS, GASTRIC MOTILITY DISORDERS, BRAIN TRAUMA | ELI LILLY AND COMPANY | 2002-10-15 | — | — | US | disclosed |
| EP-0982304-B1 | Piperidine derivatives having effects on serotonin related systems | LILLY CO ELI (US) | 2002-10-02 | — | — | EP | disclosed |
| US-6436964-B1 | HETEROCYCLIC AMINES, USED AS SERETONIN REUPTAKE INHIBITORS AND RECEPTOR ANTAGONISTS, ANTIDEPRESSANTS | ELI LILLY AND COMPANY | 2002-08-20 | — | — | US | disclosed |
| EP-1220853-A1 | PIPERIDINE DERIVATIVES AS SEROTONINE REUPTAKE INHIBITORS | ELI LILLY AND COMPANY (US) | 2002-07-10 | — | — | EP | disclosed |
| US-6353008-B1 | SEROTONIN REUPTAKE INHIBITOR AS ANTIDEPRESSANTS | ELI LILLY AND COMPANY | 2002-03-05 | — | — | US | disclosed |
| EP-1146045-A1 | Piperidine derivatives having effects on serotonin related systems | ELI LILLY AND COMPANY (US) | 2001-10-17 | — | — | EP | disclosed |
| EP-1100501-A1 | PYRROLIDINE AND PYRROLINE DERIVATIVES HAVING EFFECTS ON SEROTONIN RELATED SYSTEMS | ELI LILLY AND COMPANY (US) | 2001-05-23 | — | — | EP | disclosed |
| EP-1091741-A1 | AZEPINE DERIVATIVES HAVING EFFECTS ON SEROTONIN RELATED SYSTEMS | ELI LILLY AND COMPANY (US) | 2001-04-18 | — | — | EP | disclosed |
| WO-2001023381-A1 | PIPERIDINE DERIVATIVES AS REUPTAKE INHIBITORS | ELI LILLY AND COMPANY (US) | 2001-04-05 | — | — | WO | disclosed |
| WO-2001023380-A1 | PIPERIDINE DERIVATIVES AS SEROTONINE REUPTAKE INHIBITORS | ELI LILLY AND COMPANY (US) | 2001-04-05 | — | — | WO | disclosed |
| EP-0982304-A1 | Piperidine derivatives having effects on serotonin related systems | ELI LILLY AND COMPANY (US) | 2000-03-01 | — | — | EP | disclosed |
| WO-2000000203-A1 | AZEPINE DERIVATIVES HAVING EFFECTS ON SEROTONIN RELATED SYSTEMS | ELI LILLY AND COMPANY (US) | 2000-01-06 | — | — | WO | disclosed |
| WO-2000000196-A1 | PYRROLIDINE AND PYRROLINE DERIVATIVES HAVING EFFECTS ON SEROTONIN RELATED SYSTEMS | ELI LILLY AND COMPANY (US) | 2000-01-06 | — | — | WO | disclosed |
| WO-2000000198-A1 | PIPERIDINE DERIVATIVES HAVING EFFECTS ON SEROTONIN RELATED SYSTEMS | ELI LILLY AND COMPANY (US) | 2000-01-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020193590-A1 | Azepine derivatives having effects on serotonin related systems | HTR2A, HTR1A, HTR5A | SMN1; SMN2 2461/4885CYP3A4 314/4885LMNA 4347/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.