Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 2/20 | 0.69 |
| ▸ | ACE | P12821 | 8/20 | 0.66 |
| ▸ | MME | P08473 | 7/20 | 0.62 |
| ▸ | ACE2 | Q9BYF1 | 7/20 | 0.62 |
| ▸ | CPA1 | P15085 | 5/20 | 0.62 |
| ▸ | CA2 | P00918 | 2/20 | 0.62 |
| ▸ | CA1 | P00915 | 1/20 | 0.62 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.61 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.61 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.60 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.60 |
| ▸ | CTSB | P07858 | 1/20 | 0.59 |
| ▸ | CTSS | P25774 | 1/20 | 0.59 |
| ▸ | CTSK | P43235 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10033681 | 1.00 | PTPN1 (0.69) | PTPN1ACEMMEACE2CPA1 | |
| SCHEMBL8196220 | 0.94 | PTPN1 (0.74) | PTPN1ACEMMEACE2CPA1 | |
| SCHEMBL2632872 | 0.94 | PTPN1 (0.74) | PTPN1ACEMMEACE2CPA1 | |
| SCHEMBL111236 | 0.92 | ACE (0.76) | PTPN1ACEMMECA2CA1 | |
| SCHEMBL528464 | 0.92 | ACE (0.76) | PTPN1ACEMMECA2CA1 | |
| SCHEMBL111235 | 0.92 | ACE (0.76) | PTPN1ACEMMECA2CA1 | |
| SCHEMBL6513134 | 0.91 | CA2 (0.68) | PTPN1ACEMMEACE2CPA1 | |
| Hydrochloric Acid SCHEMBL10622640 | 0.90 | ACE (0.74) | PTPN1ACEMMECA2CA1 | |
| SCHEMBL28419446 | 0.90 | ACE (0.74) | PTPN1ACEMMECA2CA1 | |
| SCHEMBL28419447 | 0.90 | ACE (0.74) | PTPN1ACEMMECA2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2480523-B1 | PROCESS FOR MANUFACTURE OF N-ACYLBPHENYL ALANINE | ZHEJIANG JIUZHOU PHARM CO LTD (CN) | 2017-03-01 | — | — | EP | disclosed |
| US-20160115118-A1 | PROCESS FOR THE MANUFACTURE OF N-ACYLBIPHENYL ALANINE | ZHEJIANG JIUZHOU PHARMACEUTICAL CO., LTD. (CN) | 2016-04-28 | — | — | US | disclosed |
| US-20160115118-A1 | PROCESS FOR THE MANUFACTURE OF N-ACYLBIPHENYL ALANINE | ZHEJIANG JIUZHOU PHARMACEUTICAL CO., LTD. (CN) | 2016-04-28 | — | — | US | disclosed |
| US-9242927-B2 | Process for the manufacture of N-acylbiphenyl alanine | ZHEJIANG JIUZHOU PHARMACEUTICAL CO., LTD (CN) | 2016-01-26 | — | — | US | disclosed |
| US-9242927-B2 | Process for the manufacture of N-acylbiphenyl alanine | ZHEJIANG JIUZHOU PHARMACEUTICAL CO., LTD (CN) | 2016-01-26 | — | — | US | disclosed |
| US-9181175-B2 | Process for manufacture and resolution of 2-acylamino-3-diphenylpropanoic acid | Zhejiang Jiuzhous Pharmaceutical Co., Ltd. (CN) | 2015-11-10 | — | — | US | disclosed |
| US-9181175-B2 | Process for manufacture and resolution of 2-acylamino-3-diphenylpropanoic acid | Zhejiang Jiuzhous Pharmaceutical Co., Ltd. (CN) | 2015-11-10 | — | — | US | disclosed |
| EP-2387558-B1 | PROCESS FOR MANUFACTURE AND RESOLUTION OF 2-ACYLAMINO-3-DIPHENYLPROPANOIC ACID | ZHEJIANG JIUZHOU PHARM CO LTD (CN) | 2014-08-27 | — | — | EP | disclosed |
| US-20140179947-A1 | PROCESS FOR MANUFACTURE AND RESOLUTION OF 2-ACYLAMINO-3-DIPHENYLPROPANOIC ACID | ZHEJIANG JIUZHOU PHARMACEUTICAL CO., LTD. (CN) | 2014-06-26 | — | — | US | disclosed |
| US-20140179947-A1 | PROCESS FOR MANUFACTURE AND RESOLUTION OF 2-ACYLAMINO-3-DIPHENYLPROPANOIC ACID | ZHEJIANG JIUZHOU PHARMACEUTICAL CO., LTD. (CN) | 2014-06-26 | — | — | US | disclosed |
| US-20140142320-A1 | Process for the Manufacture of N-acylbiphenyl alanine | ZHEJIANG JIUZHOU PHARMACEUTICAL CO., LTD. (CN) | 2014-05-22 | — | — | US | disclosed |
| US-20140142320-A1 | Process for the Manufacture of N-acylbiphenyl alanine | ZHEJIANG JIUZHOU PHARMACEUTICAL CO., LTD. (CN) | 2014-05-22 | — | — | US | disclosed |
| US-20130172572-A1 | Process for Manufacture of N-acylbiphenyl alanine | ZHEJIANG JIUZHOU PHARMACEUTICAL CO., LTD. (CN) | 2013-07-04 | — | — | US | disclosed |
| US-20130172572-A1 | Process for Manufacture of N-acylbiphenyl alanine | ZHEJIANG JIUZHOU PHARMACEUTICAL CO., LTD. (CN) | 2013-07-04 | — | — | US | disclosed |
| CN-101555211-B | Chemical synthesis method of 2-acylamino-3-biphenyl propionic acid | ZHEJIANG JIUZHOU PHARM CO LTD | 2012-01-25 | — | — | CN | disclosed |
| US-20120016151-A1 | PROCESS FOR MANUFACTURE AND RESOLUTION OF 2-ACYLAMINO-3-DIPHENYLPROPANOIC ACID | NOVARTIS AG (CH) | 2012-01-19 | — | — | US | disclosed |
| US-20120016151-A1 | PROCESS FOR MANUFACTURE AND RESOLUTION OF 2-ACYLAMINO-3-DIPHENYLPROPANOIC ACID | NOVARTIS AG (CH) | 2012-01-19 | — | — | US | disclosed |
| WO-2011035569-A1 | PROCESS FOR MANUFACTURE OF N-ACYLBPHENYL ALANINE | ZHEJIANG JIUZHOU PHARMACEUTICAL CO., LTD. (CN) | 2011-03-31 | — | — | WO | disclosed |
| WO-2010081410-A1 | PROCESS FOR MANUFACTURE AND RESOLUTION OF 2-ACYLAMINO-3-DIPHENYLPROPANOIC ACID | ZHEJIANG JIUZHOU PHARMACEUTICAL CO., LTD. (CN) | 2010-07-22 | — | — | WO | disclosed |
| CN-101555211-A | Chemical synthesis method of 2-acylamino-3-biphenyl propionic acid | ZHEJIANG JIUZHOU PHARMACEUTICA (CN) | 2009-10-14 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160115118-A1 | PROCESS FOR THE MANUFACTURE OF N-ACYLBIPHENYL ALANINE | ANPEP, DNPEP, ENPEP | PTPN1 3273/4885ACE 31/4885MME 7/4885 |
| US-20140179947-A1 | PROCESS FOR MANUFACTURE AND RESOLUTION OF 2-ACYLAMINO-3-DIPHENYLPROPANOIC ACID | DNPEP, MME, DPP7 | PTPN1 3065/4885ACE 29/4885MME 2/4885 |
| US-20120016151-A1 | PROCESS FOR MANUFACTURE AND RESOLUTION OF 2-ACYLAMINO-3-DIPHENYLPROPANOIC ACID | DNPEP, MME, DPP7 | PTPN1 3065/4885ACE 29/4885MME 2/4885 |
| US-20140142320-A1 | Process for the Manufacture of N-acylbiphenyl alanine | ANPEP, DNPEP, ENPEP | PTPN1 3273/4885ACE 31/4885MME 7/4885 |
| US-20130172572-A1 | Process for Manufacture of N-acylbiphenyl alanine | ANPEP, DNPEP, RNPEP | PTPN1 3699/4885ACE 35/4885MME 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.