Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 6/20 | 0.52 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.49 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.48 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.48 |
| ▸ | AR | P10275 | 2/20 | 0.48 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.45 |
| ▸ | KIF11 | P52732 | 2/20 | 0.43 |
| ▸ | SLC22A12 | Q96S37 | 4/20 | 0.42 |
| ▸ | ACLY | P53396 | 1/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1627994 | 0.81 | SLC22A12 (0.49) | PGRNR3C1NR3C2ARSLC22A12 | |
| SCHEMBL2129695 | 0.80 | GRM4 (0.45) | PGRNR3C1NR3C2ARGRM4 | |
| SCHEMBL13065706 | 0.79 | SLC22A12 (0.43) | PGRNR3C1NR3C2ARSLC22A12 | |
| SCHEMBL3173181 | 0.78 | GRM4 (0.48) | PGRARGRM4ABCG2ALDH1A1 | |
| SCHEMBL6863684 | 0.78 | ALDH1A1 (0.60) | PGRNR3C1NR3C2ARSLC22A12 | |
| SCHEMBL2678340 | 0.77 | SLC22A12 (0.62) | PGRNR3C1NR3C2ARKIF11 | |
| SCHEMBL12018117 | 0.75 | ADRA2C (0.54) | PGRADRA2CADRA1AADRA1BKIF11 | |
| SCHEMBL6223374 | 0.75 | GRM4 (0.44) | PGRGRM4SLC22A12ABCG2HSP90AA1 | |
| SCHEMBL6223375 | 0.75 | GRM4 (0.44) | PGRGRM4SLC22A12ABCG2HSP90AA1 | |
| SCHEMBL4624565 | 0.75 | TRPV4 (0.43) | PGRNR3C1NR3C2ARSLC22A12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0973730-B1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2004-06-16 | — | — | EP | disclosed |
| WO-2002072760-A2 | PCRA HELICASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-09-19 | — | — | WO | disclosed |
| US-6294531-B1 | AMINOALKANOLS AS BLOOD COAGULANTS | SMITHKLINE BEECHAM CORPORATION | 2001-09-25 | — | — | US | disclosed |
| CN-1259120-A | Calcilytic compounds | SMITHKLINE BEECHAM CORP (US) | 2000-07-05 | — | — | CN | disclosed |
| EP-0973730-A1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-01-26 | — | — | EP | disclosed |
| WO-1998045255-A1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-10-15 | — | — | WO | disclosed |