Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A2 | O15244 | 7/20 | 1.00 |
| ▸ | SLC22A1 | O15245 | 7/20 | 1.00 |
| ▸ | SLC22A3 | O75751 | 7/20 | 1.00 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | PLAU | P00749 | 7/20 | 0.63 |
| ▸ | HTR3E | A5X5Y0 | 5/20 | 0.63 |
| ▸ | HTR3B | O95264 | 5/20 | 0.63 |
| ▸ | HTR3A | P46098 | 5/20 | 0.63 |
| ▸ | HTR3D | Q70Z44 | 5/20 | 0.63 |
| ▸ | HTR3C | Q8WXA8 | 5/20 | 0.63 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.63 |
| ▸ | ACR | P10323 | 1/20 | 0.63 |
| ▸ | CA12 | O43570 | 2/20 | 0.54 |
| ▸ | CA1 | P00915 | 2/20 | 0.54 |
| ▸ | CA2 | P00918 | 2/20 | 0.54 |
| ▸ | CA9 | Q16790 | 2/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16489286 | 0.86 | SLC22A2 (0.76) | SLC22A2SLC22A1SLC22A3PRSS1ACR | |
| SCHEMBL19038559 | 0.84 | SLC22A2 (0.71) | SLC22A2SLC22A1SLC22A3POLBPLAU | |
| SCHEMBL6437580 | 0.77 | HTR3E (1.00) | SLC22A2SLC22A1SLC22A3POLBPLAU | |
| SCHEMBL4983449 | 0.77 | SIGMAR1 (0.66) | SLC22A2SLC22A1SLC22A3CYP2D6TDP1 | |
| SCHEMBL4980439 | 0.75 | SLC22A2 (0.59) | SLC22A2SLC22A1SLC22A3PLAUHTR3E | |
| SCHEMBL166140 | 0.73 | SLC22A2 (1.00) | SLC22A2SLC22A1SLC22A3POLBPLAU | |
| SCHEMBL6183452 | 0.72 | SLC22A2 (0.57) | SLC22A2SLC22A1SLC22A3PLAUHTR3E | |
| SCHEMBL742186 | 0.72 | SLC22A2 (0.56) | SLC22A2SLC22A1SLC22A3CA1CA2 | |
| SCHEMBL13632763 | 0.72 | SLC22A2 (0.56) | SLC22A2SLC22A1SLC22A3CA1CA2 | |
| SCHEMBL1738380 | 0.72 | POLB (0.82) | SLC22A2SLC22A1SLC22A3POLBPLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6787569-B1 | INHIBITORS OF NEUROTRANSMITTER (E.G., GLUTAMATE) RELEASE FROM ISCHEMIC NEURONAL CELLS; N,N-DISUBSTITUTED GUANIDINES; NEUROLOGICAL CONDITIONS SUCH AS EPILEPSY, NEURODEGENERATIVE CONDITIONS AND/OR NERVE CELL DEATH FROM STROKE OR HEART ATTACK | CAMBRIDGE NEUROSCIENCE, INC. | 2004-09-07 | — | — | US | disclosed |
| US-6288123-B1 | CENTRAL NERVOUS SYSTEM DISORDERS | CAMBRIDGE NEUROSCIENCES, INC. | 2001-09-11 | — | — | US | disclosed |
| US-6143791-A | NERVOUS SYSTEM DISORDERS | CAMBRIDGE NEUROSCIENCE, INC. (US) | 2000-11-07 | — | — | US | disclosed |
| WO-1999002145-A1 | COMBINATION DRUG THERAPIES COMPRISING AMINOGLYCOSIDE ANTIBIOTICS AND N,N'-DISUBSTITUTED GUANIDINES | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1999-01-21 | — | — | WO | disclosed |