Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 5/20 | 1.00 |
| ▸ | HTR3B | O95264 | 5/20 | 1.00 |
| ▸ | HTR3A | P46098 | 5/20 | 1.00 |
| ▸ | HTR3D | Q70Z44 | 5/20 | 1.00 |
| ▸ | HTR3C | Q8WXA8 | 5/20 | 1.00 |
| ▸ | PLAU | P00749 | 5/20 | 1.00 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | SLC22A2 | O15244 | 6/20 | 0.63 |
| ▸ | SLC22A1 | O15245 | 6/20 | 0.63 |
| ▸ | SLC22A3 | O75751 | 6/20 | 0.63 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.63 |
| ▸ | ACR | P10323 | 1/20 | 0.63 |
| ▸ | NOS1 | P29475 | 5/20 | 0.61 |
| ▸ | NOS3 | P29474 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | NOS2 | P35228 | 2/20 | 0.58 |
| ▸ | BLM | P54132 | 2/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19038557 | 0.84 | HTR3E (0.71) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL1387842 | 0.78 | HTR3E (0.63) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL6858736 | 0.77 | SLC22A2 (1.00) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL11884390 | 0.77 | ITGB3 (0.71) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL8398110 | 0.77 | MEN1 (0.66) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL2464879 | 0.75 | HTR3E (1.00) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL1387705 | 0.74 | NOS1 (0.58) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL8392952 | 0.74 | HTR3E (0.58) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7811970 | 0.73 | SLC22A2 (1.00) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL28296323 | 0.72 | MEN1 (0.66) | HTR3EHTR3BHTR3AHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050026836-A1 | Composition for the treatment of damaged tissue | DACK KEVIN NEIL (GB) | 2005-02-03 | — | — | US | disclosed |
| US-20030199440-A1 | Composition for the treatment of damaged tissue | PFIZER INC. | 2003-10-23 | — | — | US | disclosed |
| EP-1242120-A2 | COMBINATIONS OF GROWTH FACTORS AND I:UPA OR I:MMP FOR THE TREATMENT OF DAMAGED TISSUE | Pfizer Limited (GB) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001049309-A2 | COMBINATIONS OF GROWTH FACTORS AND I: UPA OR I: MMP FOR THE TREATMENT OF DAMAGED TISSUE | PFIZER LIMITED (GB) | 2001-07-12 | — | — | WO | disclosed |
| US-3976643-A | FROM AN ANILINE AND CYANAMIDE | WILLIAM H. RORER, INC. (US) | 1976-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030199440-A1 | Composition for the treatment of damaged tissue | MMP1, SERPINE1, COL14A1 | HTR3E 4203/4885HTR3B 4041/4885HTR3A 4247/4885 |
| US-20050026836-A1 | Composition for the treatment of damaged tissue | MMP1, SERPINE1, COL14A1 | HTR3E 4203/4885HTR3B 4041/4885HTR3A 4247/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.