Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.52 |
| ▸ | CCR8 | P51685 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11206162 | 0.85 | OPRL1 (0.65) | SIGMAR1ALDH1A1OPRL1KMT2AKDM4E | |
| Hydrochloric Acid SCHEMBL11199734 | 0.84 | OPRL1 (0.64) | SIGMAR1ALDH1A1OPRL1KMT2AKDM4E | |
| Hydrochloric Acid SCHEMBL9312362 | 0.83 | ALDH1A1 (0.68) | SIGMAR1ALDH1A1OPRL1CCR8L3MBTL1 | |
| SCHEMBL4816046 | 0.79 | ALDH1A1 (0.80) | SIGMAR1ALDH1A1OPRL1L3MBTL1KMT2A | |
| Hydrochloric Acid SCHEMBL6288091 | 0.78 | ALDH1A1 (0.78) | SIGMAR1ALDH1A1OPRL1L3MBTL1KMT2A | |
| SCHEMBL3081018 | 0.78 | ALDH1A1 (0.60) | SIGMAR1ALDH1A1OPRL1L3MBTL1KMT2A | |
| SCHEMBL350525 | 0.78 | OPRL1 (0.65) | SIGMAR1ALDH1A1OPRL1KMT2AKDM4E | |
| SCHEMBL11195174 | 0.78 | OPRL1 (0.77) | SIGMAR1ALDH1A1OPRL1KMT2AKDM4E | |
| SCHEMBL664827 | 0.77 | CCR3 (0.58) | SIGMAR1ALDH1A1OPRL1CCR8KMT2A | |
| Hydrochloric Acid SCHEMBL11194779 | 0.77 | ALDH1A1 (0.59) | SIGMAR1ALDH1A1OPRL1L3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6806283-B2 | SUCH AS SPIRO(9,10-DIHYDROANTHRACENE)-9,3'-PYRROLIDINE; FOR USE AS ANTIDEPRESSANT AND ANTIANXIETY AGENTS | VIRGINIA COMMONWEALTH UNIVERSITY | 2004-10-19 | — | — | US | disclosed |
| US-20030232872-A1 | Selective serotonin receptor antagonists and therapeutic applications thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2003-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030232872-A1 | Selective serotonin receptor antagonists and therapeutic applications thereof | HTR2A, HTR7, HTR1A | SIGMAR1 114/4885ALDH1A1 1660/4885OPRL1 68/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.