Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | PER2 | O15055 | 1/20 | 0.30 |
| ▸ | CRY1 | Q16526 | 1/20 | 0.30 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.30 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6857706 | 0.81 | NPSR1 (0.39) | PGRSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL6864231 | 0.72 | NR3C1 (0.47) | PGRMEN1KMT2AALDH1A1NR3C1 | |
| SCHEMBL6863864 | 0.72 | MEN1 (0.39) | PGRCSF1RSMN1; SMN2MEN1KMT2A | |
| SCHEMBL1628532 | 0.70 | NPSR1 (0.42) | PGRCSF1RSMN1; SMN2MEN1KMT2A | |
| SCHEMBL6862061 | 0.67 | ALDH1A1 (0.49) | PGRNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL6857886 | 0.66 | MLYCD (0.43) | PGRCSF1RNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1291291 | 0.60 | ALDH1A1 (0.47) | PGRNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL6151699 | 0.59 | SLC6A4 (0.46) | ALDH1A1LMNA | |
| SCHEMBL12017943 | 0.58 | NPC1 (0.60) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL4207749 | 0.58 | ALDH1A1 (0.59) | PGRSMN1; SMN2MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0973730-B1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2004-06-16 | — | — | EP | disclosed |
| US-6294531-B1 | AMINOALKANOLS AS BLOOD COAGULANTS | SMITHKLINE BEECHAM CORPORATION | 2001-09-25 | — | — | US | disclosed |
| EP-0973730-A1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-01-26 | — | — | EP | disclosed |
| WO-1998045255-A1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-10-15 | — | — | WO | disclosed |