Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 5/20 | 0.45 |
| ▸ | CNR1 | P21554 | 3/20 | 0.45 |
| ▸ | PTGES | O14684 | 3/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6857706 | 0.87 | NPSR1 (0.39) | LMNAALDH1A1NPSR1MAPTPGR | |
| SCHEMBL6864499 | 0.80 | NR3C1 (0.57) | NR3C1LMNAALDH1A1NPSR1CNR2 | |
| SCHEMBL6864234 | 0.79 | NR3C1 (0.50) | NR3C1LMNAALDH1A1NPSR1CNR2 | |
| SCHEMBL6865614 | 0.76 | ALDH1A1 (0.64) | NR3C1LMNAALDH1A1NPSR1CNR2 | |
| SCHEMBL6861888 | 0.72 | PGR (0.36) | NR3C1LMNAALDH1A1MAPTPGR | |
| SCHEMBL22273579 | 0.70 | NR3C1 (0.53) | NR3C1LMNAALDH1A1CNR2CNR1 | |
| SCHEMBL22273557 | 0.70 | MEN1 (0.54) | NR3C1LMNAALDH1A1CNR2CNR1 | |
| SCHEMBL8169333 | 0.70 | NR3C1 (0.54) | NR3C1LMNAALDH1A1NPSR1CNR2 | |
| SCHEMBL8168003 | 0.70 | ALDH1A1 (0.45) | NR3C1LMNAALDH1A1NPSR1CNR2 | |
| SCHEMBL8171446 | 0.69 | ALDH1A1 (0.44) | NR3C1LMNAALDH1A1NPSR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0973730-B1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2004-06-16 | — | — | EP | disclosed |
| US-6294531-B1 | AMINOALKANOLS AS BLOOD COAGULANTS | SMITHKLINE BEECHAM CORPORATION | 2001-09-25 | — | — | US | disclosed |
| EP-0973730-A1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-01-26 | — | — | EP | disclosed |
| WO-1998045255-A1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-10-15 | — | — | WO | disclosed |