Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RORC | P51449 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6866133 | 0.83 | TP53 (0.48) | RXFP1SMN1; SMN2NPC1LMNAPIK3CD | |
| SCHEMBL6868620 | 0.79 | TACR1 (0.54) | RXFP1SMN1; SMN2PIK3CDTP53KMT2A | |
| SCHEMBL6871144 | 0.77 | THRB (0.50) | RXFP1THRBLMNAMAPTMEN1 | |
| SCHEMBL6872467 | 0.76 | THRB (0.46) | RXFP1THRBLMNAMAPTMEN1 | |
| SCHEMBL6862190 | 0.75 | MEN1 (0.54) | RXFP1SMN1; SMN2NPC1THRBLMNA | |
| SCHEMBL12126827 | 0.74 | NPC1 (0.50) | RXFP1SMN1; SMN2NPC1LMNAMAPT | |
| SCHEMBL17964234 | 0.72 | ALDH1A1 (0.53) | SMN1; SMN2NPC1LMNAMAPTMEN1 | |
| SCHEMBL3870552 | 0.67 | AKT1 (0.44) | RXFP1SMN1; SMN2NPC1THRBMAPT | |
| SCHEMBL6871101 | 0.67 | ALDH1A1 (0.47) | SMN1; SMN2NPC1LMNAMAPTMEN1 | |
| SCHEMBL6868503 | 0.67 | KMT2A (0.64) | RXFP1SMN1; SMN2NPC1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1187814-B1 | 5-PHENYL-PYRIMIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2004-08-18 | — | — | EP | disclosed |
| US-6756380-B1 | NEUROKININ 1 RECEPTOR ANTAGONISTS | HOFFMANN-LA ROCHE INC. | 2004-06-29 | — | — | US | disclosed |
| EP-1187814-A2 | 5-PHENYL-PYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-03-20 | — | — | EP | disclosed |
| WO-2000073278-A2 | 5-PHENYL-PYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-12-07 | — | — | WO | disclosed |