Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 8/20 | 0.63 |
| ▸ | GNRHR | P30968 | 4/20 | 0.52 |
| ▸ | HTR2A | P28223 | 3/20 | 0.51 |
| ▸ | HTR1A | P08908 | 3/20 | 0.51 |
| ▸ | HTR7 | P34969 | 3/20 | 0.51 |
| ▸ | HTR5A | P47898 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.51 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | CDK1 | P06493 | 2/20 | 0.49 |
| ▸ | CDK2 | P24941 | 2/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.48 |
| ▸ | HTR3B | O95264 | 1/20 | 0.48 |
| ▸ | NCF1 | P14598 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3274724 | 0.85 | GNRHR (0.70) | GNRHR | |
| SCHEMBL3279270 | 0.83 | HTR6 (0.51) | HTR6GNRHRCDK1CDK2MKNK1 | |
| SCHEMBL6637856 | 0.78 | HTR6 (0.64) | HTR6HTR2AHTR1AHTR7HTR5A | |
| SCHEMBL6862878 | 0.78 | HTR6 (0.51) | HTR6HTR2AHTR1AHTR7HTR5A | |
| SCHEMBL5363679 | 0.75 | GNRHR (0.66) | HTR6GNRHRHTR2AHTR1AHTR2C | |
| SCHEMBL3463336 | 0.74 | HTR6 (0.55) | HTR6HTR2AHTR1AHTR7HTR5A | |
| SCHEMBL8693721 | 0.72 | PARP1 (0.54) | HTR2ACYP1A2CYP2D6GRIN2BHTR2C | |
| SCHEMBL13384132 | 0.71 | GNRHR (0.62) | GNRHR | |
| SCHEMBL31027957 | 0.71 | DHODH (0.59) | CYP1A2CYP2D6GRIN2BDHODHPARP1 | |
| SCHEMBL532061 | 0.70 | ACHE (0.68) | HTR3AHSD17B10PARP1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6710044-B2 | Technical field | NEUROSEARCH A/S (DK) | 2004-03-23 | — | — | US | disclosed |
| US-6503925-B1 | Treating anxiety, anesthesia, and epilepsy | NEUROSEARCH A/S (DK) | 2003-01-07 | — | — | US | disclosed |
| US-6218547-B1 | 1-phenyl-benzimidazole compounds and their use as GABA-a receptor modulators | NEUROSEARCH A/S (DK) | 2001-04-17 | — | — | US | disclosed |