Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 7/20 | 0.51 |
| ▸ | NCF1 | P14598 | 4/20 | 0.51 |
| ▸ | HTR1A | P08908 | 3/20 | 0.51 |
| ▸ | HTR7 | P34969 | 3/20 | 0.51 |
| ▸ | HTR2A | P28223 | 3/20 | 0.51 |
| ▸ | HTR5A | P47898 | 2/20 | 0.51 |
| ▸ | HTR3A | P46098 | 2/20 | 0.51 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.51 |
| ▸ | HTR3B | O95264 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | HTR1D | P28221 | 1/20 | 0.51 |
| ▸ | HTR1B | P28222 | 1/20 | 0.51 |
| ▸ | MTOR | P42345 | 1/20 | 0.51 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.51 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13324655 | 0.85 | HDAC6 (0.50) | HTR1AHTR3A | |
| SCHEMBL3274856 | 0.85 | HTR6 (0.45) | HTR6NCF1HTR1AHTR7HTR2A | |
| SCHEMBL20168047 | 0.78 | ADRB1 (0.51) | HTR6NCF1HTR1AHTR7HTR2A | |
| SCHEMBL6862876 | 0.78 | HTR6 (0.63) | HTR6NCF1HTR1AHTR7HTR2A | |
| SCHEMBL4171704 | 0.73 | HTR6 (0.56) | HTR6NCF1HTR1AHTR7HTR2A | |
| SCHEMBL10633864 | 0.71 | HTR6 (0.50) | HTR6NCF1HTR1AHTR7HTR2A | |
| SCHEMBL27761849 | 0.71 | NPC1 (0.56) | HSD17B10ALDH1A1HPGDKDM4ENPC1 | |
| SCHEMBL27786234 | 0.70 | HTR3A (0.60) | HTR6HTR1AHTR7HTR2AHTR5A | |
| SCHEMBL532061 | 0.70 | ACHE (0.68) | HTR3AHSD17B10ALDH1A1HPGDKDM4E | |
| SCHEMBL3289568 | 0.70 | HTR2A (0.50) | HTR6NCF1HTR1AHTR7HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6710044-B2 | Technical field | NEUROSEARCH A/S (DK) | 2004-03-23 | — | — | US | disclosed |
| US-6503925-B1 | Treating anxiety, anesthesia, and epilepsy | NEUROSEARCH A/S (DK) | 2003-01-07 | — | — | US | disclosed |
| US-6218547-B1 | 1-phenyl-benzimidazole compounds and their use as GABA-a receptor modulators | NEUROSEARCH A/S (DK) | 2001-04-17 | — | — | US | disclosed |