SCHEMBL6863189

SCHEMBL6863189

CCc1c(Cc2[nH]c(Cc3[nH]c(C=O)c(C)c3CC)c(CC)c2CC)[nH]c(C=O)c1C

nearest known ligand 0.45

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
IGF1R P08069 1/20 0.33
ALDH1A1 P00352 1/20 0.33
POLB P06746 1/20 0.33
KMT2A Q03164 1/20 0.33
P2RX7 Q99572 1/20 0.31
HSD17B10 Q99714 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13228907 0.96 ALDH1A1 (0.34) IGF1RALDH1A1POLBKMT2AP2RX7
SCHEMBL2401165 0.89 P2RX7 (0.33) ALDH1A1KMT2AP2RX7HSD17B10
SCHEMBL8719717 0.86 IGF1R (0.31) IGF1R
SCHEMBL4107546 0.86 P2RX7 (0.34) IGF1RALDH1A1POLBKMT2AP2RX7
SCHEMBL22674288 0.85 P2RX7 (0.30) P2RX7
SCHEMBL14864027 0.81 P2RX7 (0.36) ALDH1A1POLBKMT2AP2RX7HSD17B10
SCHEMBL4279732 0.80
SCHEMBL7689059 0.79 KMT2A (0.36) IGF1RALDH1A1POLBKMT2AP2RX7
SCHEMBL29954782 0.78 ALDH1A1 (0.37) IGF1RALDH1A1POLBKMT2AHSD17B10
SCHEMBL8719716 0.77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-3530529-B2 2004-05-24 JP claimed
US-5569759-A MAGNETIC RESONANCE IMAGING; TUMOR THERAPY BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM (US) 1996-10-29 US claimed
EP-0623134-A1 METAL COMPLEXES OF WATER SOLUBLE TEXAPHYRINS BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 1994-11-09 EP claimed
WO-1993014093-A1 METAL COMPLEXES OF WATER SOLUBLE TEXAPHYRINS BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 1993-07-22 WO claimed
EP-3283493-B1 TEXAPHYRIN-PHOSPHOLIPID CONJUGATES AND METHODS OF PREPARING SAME UNIV HEALTH NETWORK UHN (CA) 2020-11-18 EP disclosed
US-10729792-B2 Texaphyrin-phospholipid conjugates and methods of preparing same UNIVERSITY HEALTH NETWORK (CA) 2020-08-04 US disclosed
US-20180104364-A1 TEXAPHYRIN-PHOSPHOLIPID CONJUGATES AND METHODS OF PREPARING SAME UNIVERSITY HEALTH NETWORK (CA) 2018-04-19 US disclosed
US-20180104364-A1 TEXAPHYRIN-PHOSPHOLIPID CONJUGATES AND METHODS OF PREPARING SAME UNIVERSITY HEALTH NETWORK (CA) 2018-04-19 US disclosed
WO-2016165006-A1 TEXAPHYRIN-PHOSPHOLIPID CONJUGATES AND METHODS OF PREPARING SAME UNIVERSITY HEALTH NETWORK (CA) 2016-10-20 WO disclosed
EP-0623134-B1 METAL COMPLEXES OF WATER SOLUBLE TEXAPHYRINS UNIV TEXAS (US) 2002-11-06 EP disclosed
US-5994535-A Water soluble texaphyrin metal complex preparation BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 1999-11-30 US disclosed
EP-0462206-B1 EXPANDED PORPHYRINS: LARGE PORPHYRIN-LIKE TRIPYRROLEDIMETHINE-DERIVED MACROCYCLES UNIV TEXAS (US) 1998-07-29 EP disclosed
US-5272142-A Expanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocycles and methods for treating tumors BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 1993-12-21 US disclosed
US-5256399-A Metallotexaphyrin complexes as photosensitizers for generation of singlet oxygen for destruction of human immunodeficiency virus BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 1993-10-26 US disclosed
US-5252720-A Medical uses BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 1993-10-12 US disclosed
WO-1993014093-A1 METAL COMPLEXES OF WATER SOLUBLE TEXAPHYRINS BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 1993-07-22 WO disclosed
US-5162509-A Process for preparing expanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocycles BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 1992-11-10 US disclosed
EP-0462206-A1 EXPANDED PORPHYRINS: LARGE PORPHYRIN-LIKE TRIPYRROLEDIMETHINE-DERIVED MACROCYCLES BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 1991-12-27 EP disclosed
WO-1990010633-A1 EXPANDED PORPHYRINS: LARGE PORPHYRIN-LIKE TRIPYRROLEDIMETHINE-DERIVED MACROCYCLES BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 1990-09-20 WO disclosed
US-4935498-A Expanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocycles BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 1990-06-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180104364-A1 TEXAPHYRIN-PHOSPHOLIPID CONJUGATES AND METHODS OF PREPARING SAME PLTP, PHOSPHO1, TEX13A IGF1R 4769/4885ALDH1A1 4042/4885POLB 4354/4885
US-10729792-B2 Texaphyrin-phospholipid conjugates and methods of preparing same PLTP, PHOSPHO1, TEX13A IGF1R 4769/4885ALDH1A1 4042/4885POLB 4354/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.