SCHEMBL6863360

SCHEMBL6863360

O=[N+]([O-])c1cc(C(F)(F)F)cc(S(F)(F)(F)(F)F)c1

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.46
TSHR P16473 3/20 0.46
CYP3A4 P08684 2/20 0.46
TDP1 Q9NUW8 2/20 0.46
HPGD P15428 1/20 0.46
ALOX15 P16050 1/20 0.46
HIF1A Q16665 1/20 0.46
TXNRD1 Q16881 1/20 0.46
TXNRD3 Q86VQ6 1/20 0.46
TXNRD2 Q9NNW7 1/20 0.46
KIF11 P52732 2/20 0.40
P2RX1 P51575 3/20 0.39
P2RX4 Q99571 1/20 0.39
P2RX7 Q99572 1/20 0.39
PTPN5 P54829 1/20 0.39
ALOX5 P09917 1/20 0.39
PTGS2 P35354 1/20 0.39
CYP19A1 P11511 1/20 0.39
TMPRSS4 Q9NRS4 1/20 0.38
MAPK1 P28482 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1996062 0.84 ALDH1A1 (0.55) ALDH1A1TSHRCYP3A4TDP1HPGD
SCHEMBL816365 0.84 CYP19A1 (0.48) ALDH1A1TSHRCYP3A4TDP1HPGD
SCHEMBL9312899 0.84 CYP19A1 (0.54) ALDH1A1TSHRCYP3A4TDP1HPGD
SCHEMBL1005841 0.84 TSHR (0.55) ALDH1A1TSHRCYP3A4TDP1HPGD
Hydrochloric Acid SCHEMBL28212666 0.82 TSHR (0.53) ALDH1A1TSHRCYP3A4TDP1HPGD
Hydrazine SCHEMBL28307217 0.80 TSHR (0.52) ALDH1A1TSHRCYP3A4TDP1HPGD
SCHEMBL29658338 0.77 TSHR (0.48) ALDH1A1TSHRCYP3A4TDP1HPGD
SCHEMBL15545359 0.77 CYP19A1 (0.41) ALDH1A1TSHRCYP3A4TDP1HIF1A
SCHEMBL1505899 0.77 TSHR (0.48) ALDH1A1TSHRCYP3A4TDP1HPGD
SCHEMBL2976324 0.76 ALDH1A1 (0.47) ALDH1A1TSHRCYP3A4TDP1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6806388-B2 Polyfluorinated aromatic or heterocyclic derivatives with sulphurpentalfluoride group(s) F2 CHEMICALS LIMITED (GB) 2004-10-19 US claimed
EP-1341756-A1 POLYFLUORINATED AROMATIC OR HETEROCYCLIC DERIVATIVES WITH SULPHURPENTAFLUORIDE GROUP(S) F2 Chemicals Limited (GB) 2003-09-10 EP claimed
US-20030096999-A1 Polyfluorinated aromatic or heterocyclic derivatives with sulphurpentalfuoride group(s) F2 CHEMICALS LIMITED (GB) 2003-05-22 US claimed
WO-2002042263-A1 POLYFLUORINATED AROMATIC OR HETEROCYCLIC DERIVATIVES WITH SULPHURPENTAFLUORIDE GROUP(S) F2 CHEMICALS LIMITED (GB) 2002-05-30 WO claimed
EP-1341756-A1 POLYFLUORINATED AROMATIC OR HETEROCYCLIC DERIVATIVES WITH SULPHURPENTAFLUORIDE GROUP(S) F2 Chemicals Limited (GB) 2003-09-10 EP disclosed
US-20030096999-A1 Polyfluorinated aromatic or heterocyclic derivatives with sulphurpentalfuoride group(s) F2 CHEMICALS LIMITED (GB) 2003-05-22 US disclosed
WO-2002042263-A1 POLYFLUORINATED AROMATIC OR HETEROCYCLIC DERIVATIVES WITH SULPHURPENTAFLUORIDE GROUP(S) F2 CHEMICALS LIMITED (GB) 2002-05-30 WO disclosed