Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | PLOD2 | O00469 | 2/20 | 0.58 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.56 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.53 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.51 |
| ▸ | WNT3A | P56704 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | APP | P05067 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.49 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.49 |
| ▸ | F7 | P08709 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30109394 | 1.00 | ALDH1A1 (0.60) | ALDH1A1PLOD2TBXAS1HDAC1HDAC8 | |
| SCHEMBL30489909 | 0.87 | PLOD2 (0.67) | ALDH1A1PLOD2TBXAS1HDAC1HDAC8 | |
| SCHEMBL82139 | 0.87 | PLOD2 (0.67) | ALDH1A1PLOD2TBXAS1HDAC1HDAC8 | |
| SCHEMBL7075878 | 0.86 | PLOD2 (0.69) | ALDH1A1PLOD2TBXAS1HDAC1HDAC8 | |
| Hydrochloric Acid SCHEMBL6946997 | 0.85 | PLOD2 (0.65) | ALDH1A1PLOD2TBXAS1HDAC1HDAC8 | |
| SCHEMBL17895063 | 0.84 | ALDH1A1 (0.66) | ALDH1A1PLOD2TBXAS1KMT2AMEN1 | |
| SCHEMBL6158655 | 0.84 | TBXAS1 (0.58) | ALDH1A1PLOD2TBXAS1HDAC1HDAC8 | |
| Hydrochloric Acid SCHEMBL11375570 | 0.83 | TBXAS1 (0.57) | ALDH1A1PLOD2TBXAS1HDAC1HDAC8 | |
| SCHEMBL29835154 | 0.83 | PLOD2 (0.50) | ALDH1A1PLOD2TBXAS1HDAC1HDAC8 | |
| SCHEMBL17884960 | 0.83 | PLOD2 (0.50) | ALDH1A1PLOD2TBXAS1HDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230133132-A1 | NAMPT MODULATORS | CYTOKINETICS, INC. | 2023-05-04 | — | — | US | disclosed |
| US-20230133132-A1 | NAMPT MODULATORS | CYTOKINETICS, INC. | 2023-05-04 | — | — | US | disclosed |
| US-20230133132-A1 | NAMPT MODULATORS | CYTOKINETICS, INC. | 2023-05-04 | — | — | US | disclosed |
| CN-115515934-A | NAMPT modulators | 赛特凯恩蒂克公司 | 2022-12-23 | — | — | CN | disclosed |
| EP-4100393-A1 | NAMPT MODULATORS | Cytokinetics, Inc. (US) | 2022-12-14 | — | — | EP | disclosed |
| WO-2021159015-A1 | NAMPT MODULATORS | CYTOKINETICS, INC. (US) | 2021-08-12 | — | — | WO | disclosed |
| WO-2021159015-A1 | NAMPT MODULATORS | CYTOKINETICS, INC. (US) | 2021-08-12 | — | — | WO | disclosed |
| EP-0999204-B1 | NOVEL COMPOUND HAVING EFFECT OF PROMOTING NEURON DIFFERENTIATION | NIPPON KAYAKU KK (JP) | 2004-10-13 | — | — | EP | disclosed |
| US-6399606-B1 | 3-(((2R)-2-(((2-FLUOROPHENYL)AMINO)CARBONYLAMINO)-2-(METHOXY CARBONYL)ETHYLTHIO)METHYL)-4-OXO-4-(3-PYRIDYL)BUTANOIC ACID; TREATMENT OF CHEMOTHERAPY INDUCED NEUROPATHY | NIPPON KAYAKU CO., LTD. (JP) | 2002-06-04 | — | — | US | disclosed |
| US-6384063-B1 | Compound having effect of promoting neuron differentiation | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2002-05-07 | — | — | US | disclosed |
| EP-0999204-A1 | NOVEL COMPOUND HAVING EFFECT OF PROMOTING NEURON DIFFERENTIATION | Nippon Kayaku Kabushiki Kaisha (JP) | 2000-05-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230133132-A1 | NAMPT MODULATORS | NAMPT, MC4R, SIRT1 | ALDH1A1 2019/4885PLOD2 4356/4885TBXAS1 1727/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.