Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.56 |
| ▸ | IDO1 | P14902 | 2/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.47 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.46 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 2/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KMO | O15229 | 2/20 | 0.43 |
| ▸ | FYN | P06241 | 3/20 | 0.43 |
| ▸ | CDC7 | O00311 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | PRKACA | P17612 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7392070 | 0.80 | HPGDS (0.58) | HPGDSIDO1CYP11B1MAP4K4HSD17B1 | |
| SCHEMBL15747739 | 0.79 | HPGDS (0.56) | HPGDSIDO1CYP11B1MAP4K4HSD17B1 | |
| SCHEMBL17860701 | 0.79 | KDM1A (0.54) | IDO1MAP4K4HSD17B1HSD17B2KMO | |
| SCHEMBL2318238 | 0.79 | HPGDS (0.60) | HPGDSIDO1CYP11B1MAP4K4HSD17B1 | |
| SCHEMBL328396 | 0.79 | HPGDS (0.56) | HPGDSIDO1CYP11B1MAP4K4HSD17B1 | |
| SCHEMBL19992829 | 0.78 | KDM1A (0.57) | IDO1PIM1KDM4EKMO | |
| SCHEMBL20862075 | 0.77 | NPC1 (0.53) | IDO1CYP11B1PIM1MEN1KMT2A | |
| SCHEMBL15097694 | 0.77 | LDHA (0.52) | HPGDSCYP11B1MEN1KMT2A | |
| SCHEMBL12203428 | 0.76 | HPGDS (0.54) | HPGDSIDO1CYP11B1MAP4K4HSD17B1 | |
| SCHEMBL15747846 | 0.76 | HPGDS (0.57) | HPGDSIDO1CYP11B1MAP4K4HSD17B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014028334-A1 | SELECTIVE MMP INHIBITORS | SYMPHONY EVOLUTION, INC. (US) | 2014-02-20 | — | — | WO | disclosed |
| WO-2011041545-A1 | METHODS OF TREATING ANEURYSMAL DILATATION, BLOOD VESSEL WALL WEAKNESS AND SPECIFICALLY ABDOMINAL AORTIC AND THORACIC ANEURYSM USING MATRIX METALLOPROTEASE-2 INHIBITORS | SYMPHONY EVOLUTION, INC. (US) | 2011-04-07 | — | — | WO | disclosed |